The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke

  • Elaheh Heydari
  • Masoumeh Alishahi
  • Farhoodeh Ghaedrahmati
  • William Winlow
  • Seyed Esmaeil KhoshnamEmail author
  • Amir AnbiyaieeEmail author
Review Article


Stroke is the leading cause of death and physical disability worldwide. Non-coding RNAs (ncRNAs) are endogenous molecules that play key roles in the pathophysiology and retrieval processes following ischemic stroke. The potential of ncRNAs, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in neuroprotection and angiogenesis highlights their potential as targets for therapeutic intervention. In this review, we document the miRNAs and lncRNAs that have been reported to exert regulatory actions in neuroprotective and angiogenic processes through different mechanisms involving their interaction with target coding genes. We believe that exploration of the expression profiles and the possible functions of ncRNAs during the recovery processes will help comprehension of the molecular mechanisms responsible for neuroprotection and angiogenesis, and may also contribute to find biomarkers and targets for future stroke intervention.


Non-coding RNAs Ischemic Stroke Neuroprotection Angiogenesis 


Compliance with ethical standards

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial/ non-commercial or financial/ non-financial relationships that could be construed as a potential conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of BiologyTehran North Branch, Islamic Azad UniversityTehranIran
  2. 2.Immunology Department, Medical SchoolShiraz University of Medical SciencesShirazIran
  3. 3.Dipartimento di BiologiaUniversità degli Studi di Napoli, Federico IINapoliItaly
  4. 4.Honorary Research Fellow, Institute of Ageing and Chronic DiseasesUniversity of LiverpoolLiverpoolUK
  5. 5.Physiology Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIran
  6. 6.Department of Obstetrics & Gynecology, School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

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