GRM7 polymorphisms and risk of schizophrenia in Iranian population

  • Iman Azari
  • Reza Hosseinpour Moghadam
  • Hamid Fallah
  • Rezvan Noroozi
  • Soudeh Ghafouri-FardEmail author
  • Mohammad TaheriEmail author
Original Article


The role of metabotropic glutamate receptors in the pathogenesis of schizophrenia or response to antipsychotic treatment has been proposed previously. The aim of the current study was to investigate the associations between two intronic variants within GRM7 gene (rs6782011 and rs779867) and schizophrenia in Iranian population. These two single nucleotide polymorphisms (SNPs) were genotyped in 273 schizophrenic patients and 300 age and sex-matched normal controls. The frequency of A allele of the rs779867 was significantly lower in the schizophrenic patients compared with healthy subjects (OR (95% CI) = 0.71 (0.56–0.89), adjusted P value = 0.008). This SNP was associated with schizophrenia in co-dominant and dominant models (adjusted P values of 0.03 and 0.02 respectively). However, there was no difference in allele and genotype frequencies of the rs6782011 SNP between cases and controls. Consequently, the results of current study further highlight the participation of GRM7 in the pathogenesis of schizophrenia.


GRM7 Polymorphism Schizophrenia 



The current study was supported by a grant from Shahid Beheshti University of Medical Sciences.

Compliance with ethical standards

Conflict of interest

The authors declare they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medical GeneticsShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Pharmaceutics, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Phytochemistry Research CenterShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Student Research CommitteeShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran

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