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Metabolic Brain Disease

, Volume 34, Issue 1, pp 257–266 | Cite as

Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

  • Yu Qi
  • Lei Shang
  • Zhengzheng Liao
  • Hang Su
  • Huiting Jing
  • Bo Wu
  • Kaishun Bi
  • Ying JiaEmail author
Original Article
  • 146 Downloads

Abstract

Resveratrol (RSV) is a natural plant polyphenol compound which consists in red grape skins and wine in general. Plenty of previous studies have shown that resveratrol has neuroprotective effects. The primary object of this research was to study the effects of RSV on improving the cognitive function and neurodegeneration in the mouse model of Alzheimer’s disease induced by Aβ1–42, and the possible mechanism about targeting on Sirt1, which results in attenuating inflammatory response and mitochondrial dysfunction. We established the AD model of intracerebroventricular (i.c.v.) injection of Aβ1–42 and it was observed that the significant decrease in alternately of Y Maze and the quadrant dwell time percentage of Morris water maze test. Furthermore, there were significant upregulations of AMPK/ PGC-1α and downregulations of NF-κB/ IL-1β/ NLRP3 signaling pathways in the hippocampus and prefrontal cortex in AD mice. The treatments with RSV and Donepezil could significantly ameliorate all the behavioral and biochemical changes induced by Aβ1–42. It also noticeably improved the histopathological changes in the hippocampus and cortex. The results suggested that RSV might protect against cognitive deficits and neurodegeneration induced by Aβ1–42, and serve as a potential agent in treatment of AD.

Keywords

Resveratrol Alzheimer’s disease Intracerebroventricular injection Sirt1 Inflammation Mitochondrial dysfunction 

Notes

Acknowledgements

This research was supported by National Natural Science Foundation of China (No. 81573580), Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province and Key Laboratory of Quality Control of TCM of Liaoning Province (17-137-1-00).

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangChina
  2. 2.School of Basic Medical SciencesShenyang Medical CollegeShenyangChina
  3. 3.School of PharmacyShenyang Pharmaceutical UniversityShengyangChina
  4. 4.School of Functional Food and WineShenyang Pharmaceutical UniversityShenyangChina

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