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Nicotinamide ribose ameliorates cognitive impairment of aged and Alzheimer’s disease model mice

  • Xian Xie
  • Yi Gao
  • Min Zeng
  • Yi Wang
  • Tao-Feng Wei
  • Yun-Bi Lu
  • Wei-Ping Zhang
Original Article
  • 51 Downloads

Abstract

Nicotinamide adenine dinucleotide (NAD) supplementation to repair the disabled mitochondria is a promising strategy for the treatment of Alzheimer’s disease (AD) and other dementia. Nicotinamide ribose (NR) is a safe NAD precursor with high oral bioavailability, and has beneficial effects on aging. Here, we applied NR supplied food (2.5 g/kg food) to APP/PS1 transgenic AD model mice and aged mice for 3 months. Cognitive function, locomotor activity and anxiety level were assessed by standard behavioral tests. The change of body weight, the activation of microglia and astrocytes, the accumulation of Aβ and the level of serum nicotinamide phosphoribosyltransferase (NAMPT) were determined for the evaluation of pathological processes. We found that NR supplementation improved the short-term spatial memory of aged mice, and the contextual fear memory of AD mice. Moreover, NR supplementation inhibited the activation of astrocytes and the elevation of serum NAMPT of aged mice. For AD model mice, NR supplementation inhibited the accumulation of Aβ and the migration of astrocyte to Aβ. In addition, NR supplementation inhibit the body weight gain of aged and APP/PS1 mice. Thus, NR has selective benefits for both AD and aged mice, and the oral uptake of NR can be used to prevent the progression of dementia.

Keywords

Nicotinamide adenine dinucleotide (NAD) Nicotinamide ribose (NR) Alzheimer’s disease (AD) Cognition Dementia Neuroinflammation 

Notes

Acknowledgments

The authors are grateful to the Core Facilities of Zhejiang University Institute of Neuroscience for technical assistance.

This work was supported by grants from the National Key R&D Program of China (2018YFA0507700), the National Natural Sciences Foundation of China (81573400), the Zhejiang Provincial Natural Science Foundation of China (LY18H170001), and Public Technology Application Research of Zhejiang Province (2016F82G2010036).

Compliance with ethical standards

Conflict of interests

The authors have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmacology, Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineZhejiangChina
  2. 2.Hospital of StomatologyZhejiang University School of MedicineHangzhouChina
  3. 3.Zhejiang Province Key Laboratory of Mental Disorder’s ManagementZhejiang University School of MedicineZhejiangChina

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