Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers
Methamphetamine is a popular psychostimulant worldwide which causes neurotoxicity and neuroinflammation. Although previous studies have characterized potential associations between addictive drugs and fasting blood glucose, the influence of methamphetamine on the blood glucose is still largely unknown. The present study was designed to investigate the change of fasting blood glucose of methamphetamine abusers and to confirm the impairment of liver and kidney. Fasting blood glucose was significantly decreased in methamphetamine abusers and in a high-fat diet mouse model with methamphetamine treatment discontinuation. Serum level of ALT, creatine kinase and creatinine were increased in methamphetamine abusers. Serum level of ALT and AST were increased in a high-fat diet mouse model after methamphetamine injection, but there was no significant difference in the anatomy of the liver and kidney in high-fat diet treated mice with or without methamphetamine. The levels of ALT and creatinine were also increased in the methamphetamine abusers. This study demonstrated that the level of glucose was decreased in methamphetamine abusers and in high-fat diet-fed mice after methamphetamine treatment discontinuation. The effect of methamphetamine on the levels of blood glucose may provide the evidence that methamphetamine abusers should be keep energy balance due to the low blood glucose.
KeywordsMethamphetamine Serum biochemical parameters Liver Kidney
Central nervous system
High fat diet
Low density lipoproteins cholesterol
High density lipoproteins cholesterol
This work was supported by grants from the National Natural Science Foundation of China (No. 81322048 and No. 81473190).
Y.H. planned and designed the research, supervised and wrote the experiments; Y.H.Z carried out the experiments and wrote the manuscript; Y.B. participated in data acquisition and analysis; G.F.S and J.C participated in the design of study, drafted manuscript and coordinated the lab work; and X.F.C provided the comments on the manuscript, edited the writing, and involved in revising it critically for important intellectual content. All authors read and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that there are no conflicts of interest.
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