Molecular and Cellular Biochemistry

, Volume 465, Issue 1–2, pp 65–73 | Cite as

Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor

  • Zhen Wang
  • Weihua Ren
  • Fucheng Zhao
  • Yanru Han
  • Caili Liu
  • Kui JiaEmail author


Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was explored. Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and chronic mild stress administration to induce PSD symptoms and then treated with Cur. The behaviors of rats were assessed with sucrose preference and forced swim tests. The accumulation of Ca2+ and the systemic inflammatory response in rats were detected. To determine the role of P2X7R in the anti-PSD function of curcumin, the PSD mice were further administrated with P2X7R agonist and antagonist. The administration of Cur attenuated behavior disorders associated with PSD. Moreover, the Ca2+ accumulation and the inflammatory response associated with PSD were also blocked by Cur. Cur also inhibited the activation of Ca2+ channel. The induced activity of P2X7R blocked the function of Cur by maintaining the symptoms of PSD in Cur-treated rats. Collectively, the anti-PSD function of Cur was dependent on the inhibition of P2X7R, which then deactivated Ca2+ channel-mediated inflammatory response associated with PSD progression.


Ca2+ channel Curcumin Neuroinflammation Post-stroke depression P2X7 receptor 



This study was supported by the grants from the Science and Technology Research Project of Henan Province (172102310585).

Compliance with ethical standards

Conflict of interest

The authors disclose no conflict of interest.

Supplementary material

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Electronic supplementary material 1 (TIF 390 kb)
11010_2019_3668_MOESM2_ESM.docx (14 kb)
Electronic supplementary material 2 (DOCX 14 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  1. 1.Department of Integrated Chinese and Western MedicineThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiangChina

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