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Molecular and Cellular Biochemistry

, Volume 461, Issue 1–2, pp 119–126 | Cite as

TGF-β2 antagonizes IL-6-promoted cell survival

  • Yuping Du
  • Jingjie Sun
  • Xinning Liu
  • Jing Nan
  • Xiaodong Qin
  • Xiao Wang
  • Jihui Guo
  • Chenyang ZhaoEmail author
  • Jinbo YangEmail author
Article
  • 62 Downloads

Abstract

Transforming growth factor beta is a key cytokine involved in the pathogenesis of fibrosis in many organs, whereas interleukin-6 plays an important role in the regulation of inflammation. They are both potent angiogenesis inducers with opposite effects on cell survival and apoptosis. TGF-β2 induces apoptosis; in contrast, IL-6 protects cells from apoptosis. The possible interaction between these two cytokines is indicated in various disease states. In this study, we have assessed the effect of TGF-β2 on IL-6 signaling and found that TGF-β2 could strongly inhibit IL-6-induced STAT3 activation and synergy with IL-6 resulting in enhanced SOCS3 expression. Interestingly, IL-6 also slows down the decay of TGF-β2 mRNA. Consistent with this mechanism, we found that TGF-β2 could antagonize IL-6 effect on cell survival in both γ-irradiation and UV light-induced apoptosis. Taken together, the finding shows that TGF-β2 serves as a negative regulator of IL-6 signaling and antagonizes the anti-apoptosis effect of IL-6.

Keywords

IL-6 TGF-β2 STAT3 Cell survival Apoptosis 

Notes

Acknowledgements

This work was supported by Grant 31571439 from National Natural Science Foundation of China (J.Y.), Qingdao Scientific and Technological Innovation center for Marine Biomedicine Development Grant (2017-CXZX01-2-2), and startup funding of Ocean University of China (C.Z.).

Compliance with ethical standards

Conflicts of interest

The authors disclose no potential conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yuping Du
    • 1
  • Jingjie Sun
    • 1
  • Xinning Liu
    • 2
  • Jing Nan
    • 1
  • Xiaodong Qin
    • 1
  • Xiao Wang
    • 1
  • Jihui Guo
    • 1
  • Chenyang Zhao
    • 2
    Email author
  • Jinbo Yang
    • 1
    Email author
  1. 1.School of Life ScienceLanzhou UniversityLanzhouPeople’s Republic of China
  2. 2.School of Medicine and PharmacyOcean University of ChinaShandongPeople’s Republic of China

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