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C6orf106 accelerates pancreatic cancer cell invasion and proliferation via activating ERK signaling pathway

  • Xin Li
  • Ming Dong
  • Jianping Zhou
  • Dehua Zhu
  • Jinbo Zhao
  • Weiwei Sheng
Article
  • 70 Downloads

Abstract

C6orf106 was highly expressed in lung and breast cancer, and proposed as clinicopathologic factor for the development of those types of cancer. However, its expression in pancreatic cancer and the mechanism that C6orf106 functions as an oncogene has not been confirmed. In the present study, we found that C6orf106 was also up-regulated in pancreatic cancer tissues and cell lines. Furthermore, C6orf106 expression was associated with advanced T stage (P = 0.010), positive regional lymph node metastasis (P = 0.012), and advanced TNM stage (P = 0.006). In vitro experiments also showed that C6orf106 served a tumor enhancer in pancreatic cancer, through increasing the expression of Snail, Cyclin D1 and Cyclin E1, and reducing the expression of E-cadherin via activating extracellular-signal-regulated kinase (ERK)- p90-kDa ribosomal S6 kinases (P90RSK) signaling pathway. The addition of ERK inhibitor PD98059 counteracted the upregulation of Snail, Cyclin D1 and Cyclin E1, and restored the expression of E-cadherin, which indicated that C6orf106 was an upstream factor of ERK signaling pathway. Taken together, the present study indicates that C6orf106 facilitates invasion and proliferation of pancreatic cancer cells, likely via activating ERK-P90RSK signaling pathway.

Keywords

C6orf106 Pancreatic cancer ERK Invasion Proliferation 

Notes

Funding

This work was supported by the China National Science Foundation (Grant No. 81672835 to M.D.) and Scientific Research of Special-Term Professor from the Educational Department of Liaoning Province, China (Liao Cai Zhi Jiao No. 2012-512).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Xin Li
    • 1
  • Ming Dong
    • 1
  • Jianping Zhou
    • 1
  • Dehua Zhu
    • 1
  • Jinbo Zhao
    • 1
  • Weiwei Sheng
    • 1
  1. 1.Department of General Surgery, Gastrointestinal Surgery, The First HospitalChina Medical UniversityShenyangChina

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