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Predictors of Steroid Hormone Concentrations in Early Pregnancy: Results from a Multi-Center Cohort

  • Emily S. BarrettEmail author
  • Omar Mbowe
  • Sally W. Thurston
  • Samantha Butts
  • Christina Wang
  • Ruby Nguyen
  • Nicole Bush
  • J. Bruce Redmon
  • Sukrita Sheshu
  • Shanna H. Swan
  • Sheela Sathyanarayana
Article

Abstract

Objectives To identify factors predicting maternal sex steroid hormone concentrations in early pregnancy. Methods The Infant Development and the Environment Study recruited healthy pregnant women from academic medical centers in four US cities. Gold standard liquid chromatography–tandem mass spectrometry was used to measure maternal sex steroids concentrations (total testosterone [TT], free testosterone [FT], estrone [E1], estradiol [E2], and estriol [E3] concentrations) in serum samples from 548 women carrying singletons (median = 11.7 weeks gestation). Women completed questionnaires on demographic and lifestyle characteristics. Results In multivariable linear regression analyses, hormone concentrations varied in relation to maternal age, body mass index (BMI), race, and parity. Older mothers had significantly lower levels of most hormones; for every year increase in maternal age, there was a 1–2% decrease in E1, E2, TT, and FT. By contrast, each unit increase in maternal BMI was associated 1–2% lower estrogen (E1, E2, E3) levels, but 1–2% higher androgen (TT, FT) concentrations. Hormone concentrations were 4–18% lower among parous women, and for each year elapsed since last birth, TT and FT were 1–2% higher (no difference in estrogens). Androgen concentrations were 18–30% higher among Black women compared to women of other races. Fetal sex, maternal stress, and lifestyle factors (including alcohol and tobacco use) were not related to maternal steroid concentrations. Conclusions for Practice Maternal demographic factors predict sex steroid hormone concentrations during pregnancy, which is important given increasing evidence that the prenatal endocrine environment shapes future risk of chronic disease for both mother and offspring.

Keywords

Pregnancy Androgens Estrogens Fetal origins Steroid hormones 

Notes

Acknowledgements

We wish to acknowledge the contributions of the TIDES Study Team: Coordinating Center: Fan Liu, Erica Scher; UCSF: Marina Stasenko, Erin Ayash, Melissa Schirmer, Jason Farrell, Mari-Paule Thiet, Laurence Baskin; UMN: Heather L. Gray, Chelsea Georgesen, Brooke J. Rody, Carrie A. Terrell, Kapilmeet Kaur; URMC: Erin Brantley, Heather Fiore, Lynda Kochman, Lauren Parlett, Jessica Marino, William Hulbert, Robert Mevorach, Eva Pressman; UW/SCH: Kristy Ivicek, Bobbie Salveson, Garry Alcedo and the families who participated in the study. We thank the TIDES families for their participation and the residents at URMC and UCSF who assisted with birth exams. This analysis was supported by the following NIH Grants: R21ES023883, R01ES016863, R01ES06863-02S4. Additional support for the current analyses was provided by: T32ES007271, P30ES001247, P30ES005002, and UL1TR000124.

Compliance with Ethical Standards

Ethical Statement

TIDES was approved by institutional review boards at all participating institutions, and all subjects signed informed consent prior to starting any study activities.

Supplementary material

10995_2018_2705_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 15 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Emily S. Barrett
    • 1
    • 2
    • 3
    Email author
  • Omar Mbowe
    • 4
  • Sally W. Thurston
    • 4
  • Samantha Butts
    • 5
  • Christina Wang
    • 6
  • Ruby Nguyen
    • 7
  • Nicole Bush
    • 8
  • J. Bruce Redmon
    • 9
  • Sukrita Sheshu
    • 1
  • Shanna H. Swan
    • 10
  • Sheela Sathyanarayana
    • 11
    • 12
  1. 1.Department of EpidemiologyRutgers School of Public HealthPiscatawayUSA
  2. 2.Environmental and Occupational Health Sciences InstituteRutgers UniversityPiscatawayUSA
  3. 3.Department of Obstetrics and GynecologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  4. 4.Department of Biostatistics and Computational BiologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  5. 5.Department of Obstetrics and Gynecology, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  6. 6.Clinical and Translational Science InstituteHarbor-UCLA Medical Center and Los Angeles Biomedical Research InstituteLos AngelesUSA
  7. 7.Division of Epidemiology and Community HealthUniversity of Minnesota School of Public HealthMinneapolisUSA
  8. 8.Departments of Psychiatry and PediatricsUniversity of California, San Francisco School of MedicineSan FranciscoUSA
  9. 9.Department of MedicineUniversity of Minnesota School of MedicineMinneapolisUSA
  10. 10.Department of Preventive MedicineIcahn School of Medicine at Mount SinaiNew YorkUSA
  11. 11.Department of PediatricsUniversity of WashingtonSeattleUSA
  12. 12.Center for Child Health, Behavior and DevelopmentSeattle Children’s Research InstituteSeattleUSA

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