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A Review on Bioactive Porcine Peptide, Protegrin-1

  • Shruti Sunil Ranade
  • Rajasekaran RamalingamEmail author
Article
  • 14 Downloads

Abstract

Multi drug resistance is a major problem of the twenty first century. In order to combat this issue, there is an urgent need in the pharmaceutical industry, for novel therapeutic agents. Antimicrobial peptides such as protegrins which exhibit non-specific membranolytic action can be viewed as probable therapeutic agents and replace conventional antibiotics. Protegrin-1 (PG-1) is a peptide isolated from porcine leucocytes. Its primary role is its antimicrobial activity against a broad-spectrum of gram-positive as well as gram-negative bacteria and fungi. Its antagonistic activity can be accounted by its pore formation mechanism in microbial membranes. In addition, PG-1 has multiple roles viz., anticancer and antiviral activity, immunomodulatory functions and numerous applications which increase its suitability as a potential therapeutic agent. This review paper presents a comprehensive overview of biological roles, lytic mechanism of action and applications of PG-1, thus providing a thorough understanding of this β-sheet peptide, which structurally resembles defensin peptides.

Keywords

Multi-drug resistance Therapeutic agent Antimicrobial peptides Protegrin-1 

Abbreviations

AMP

Antimicrobial peptide

AFM

Atomic force microscopy

DMPC

1,2-Dimyristoyl-sn-glycero-3-phosphocholine

DLPC

Dilauroyl-sn-glycero-3-phosphocholine

DPC

Dodecylphosphocholine

DPhPC

Diphytanoylphosphatidylcholine

GIXD

Grazing incidence X-ray diffraction

MD

Molecular dynamics

NMR

Nuclear magnetic resonance

OCD

Oriented circular dichroism

PG-1

Protegrin-1

PC

Phosphatidylcholine

PE

Phosphatidylethanolamine

PG

Phosphatidylglycerol

PS

Phosphatidylserine

POPC

1-Palmitoyl-2-oleoyl-glycero-3-phosphocholine

WHO

World Health Organization

Notes

Acknowledgements

The authors thank Vellore Institute of Technology (Deemed to be University) for providing ‘VIT SEED GRANT’ for carrying out this review on protegrin-1.

Author Contributions

Conceptualization: [RR]; Literature survey, data analysis and drafting the article: [SSR]; Critical revision of article: [RR].

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Biotechnology, School of Biosciences and TechnologyVellore Institute of Technology (Deemed To Be University)VelloreIndia

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