Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis

  • Maria Wishal Asmat
  • Muhammad Haris Ramzan
  • Faiqah RamzanEmail author


Neurokinin B (NKB) is an important endogenous neuropeptide and belongs to largest neuropeptide family tachykinin. NKB is thought to contribute in luteinizing hormone secretion, estrous cycle, energy balances, dynamics of fetus in placenta, activation of ATP, in dilation of veins and contraction in uterine muscles of rat. In recent years NKB receptors are discovered in non-neuronal cells and reproductive organs i.e. pancreas, kidney, lungs, pituitary, hypothalamus etc. however there is still no publish data of NKB effect on HPT-axis. Present study is designed to investigate the effect on histomorphology of thyroid and pituitary glands and to determine the levels of thyroid stimulating hormone, tri-iodothyronine (T3) and thyroxin (T4) subsequent to the administration of variable doses of neurokinin B (i.e. 1 pg, 1 ng, 1 µg) in adult New Zealand white rabbits. For this purpose, 24 male Oryctolagus cuniculus were administered with variable doses of neurokinin B (1 pg, 1 ng, 1 µg) for 15 days. Serum levels of TSH, T3, and T4 and histomorphological parameters were evaluated following neurokinin B administration. Level of TSH, T3 and T4 increased significantly with increase in NKB concentration. An increase in serum TSH, T3 and T4 was observed, body weight of animals decreased significantly. Histomorphology of thyroid gland revealed lumen dilation and increase in cell height in thyroid gland, hyperplasia of thyrotropes in pituitary gland was evident. It has been concluded from the results that exogenous administration of neurokinin B may have a robust impact on negative feedback loop in HPT-axis.


Neurokinin B Thyroid Throid stimulating hormone Thyroxin Epithelial cells 


Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest of intellectual or financial nature with any individual or institution.


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© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Gomal Centre of Biochemistry and BiotechnologyGomal UniversityDera Ismail KhanPakistan
  2. 2.Institute of Basic Medical SciencesKhyber Medical UniversityPeshawarPakistan

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