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Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis

  • Maria Wishal Asmat
  • Muhammad Haris Ramzan
  • Faiqah RamzanEmail author
Article
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Abstract

Neurokinin B (NKB) is an important endogenous neuropeptide and belongs to largest neuropeptide family tachykinin. NKB is thought to contribute in luteinizing hormone secretion, estrous cycle, energy balances, dynamics of fetus in placenta, activation of ATP, in dilation of veins and contraction in uterine muscles of rat. In recent years NKB receptors are discovered in non-neuronal cells and reproductive organs i.e. pancreas, kidney, lungs, pituitary, hypothalamus etc. however there is still no publish data of NKB effect on HPT-axis. Present study is designed to investigate the effect on histomorphology of thyroid and pituitary glands and to determine the levels of thyroid stimulating hormone, tri-iodothyronine (T3) and thyroxin (T4) subsequent to the administration of variable doses of neurokinin B (i.e. 1 pg, 1 ng, 1 µg) in adult New Zealand white rabbits. For this purpose, 24 male Oryctolagus cuniculus were administered with variable doses of neurokinin B (1 pg, 1 ng, 1 µg) for 15 days. Serum levels of TSH, T3, and T4 and histomorphological parameters were evaluated following neurokinin B administration. Level of TSH, T3 and T4 increased significantly with increase in NKB concentration. An increase in serum TSH, T3 and T4 was observed, body weight of animals decreased significantly. Histomorphology of thyroid gland revealed lumen dilation and increase in cell height in thyroid gland, hyperplasia of thyrotropes in pituitary gland was evident. It has been concluded from the results that exogenous administration of neurokinin B may have a robust impact on negative feedback loop in HPT-axis.

Keywords

Neurokinin B Thyroid Throid stimulating hormone Thyroxin Epithelial cells 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors have no conflict of interest of intellectual or financial nature with any individual or institution.

References

  1. Al-Gahtany M, Horvath E, Kovacs K (2003) Pituitary hyperplasia. Horm-Athens 2:149–158CrossRefGoogle Scholar
  2. Åsvold BO, Vatten LJ, Nilsen TI, Bjøro T (2007) The association between TSH within the reference range and serum lipid concentrations in a population-based study. HUNT Study Eur J Endocrinol 156:181–186CrossRefGoogle Scholar
  3. Baylis PH (2003) The syndrome of inappropriate antidiuretic hormone secretion. Int J Biochem Cell Biol 35:1495–1499CrossRefGoogle Scholar
  4. Bernal J (2007) Thyroid hormone receptors in brain development and function. Nat Rev Endocrinol 3:249CrossRefGoogle Scholar
  5. Bianco AC (2013) Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc 124:26Google Scholar
  6. Bianco AC, Kim BW (2006) Deiodinases: implications of the local control of thyroid hormone action. J Clin Investig 116:2571–2579CrossRefGoogle Scholar
  7. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR (2002) Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev 23:38–89CrossRefGoogle Scholar
  8. Capen CC, Martin SL (1989) The effects of xenobiotics on the structure and function of thyroid follicular and C-cells. Toxicol Pathol 17:266–293CrossRefGoogle Scholar
  9. Cheng S-Y, Leonard JL, Davis PJ (2010) Molecular aspects of thyroid hormone actions. Endocr Rev 31:139–170CrossRefGoogle Scholar
  10. Cintado CG, Pinto FM, Devillier P, Merida A, Candenas ML (2001) Increase in neurokinin B expression and in tachykinin NK3 receptor-mediated response and expression in the rat uterus with age. J Pharmacol Exp Ther 299:934–938Google Scholar
  11. Dietrich JW, Landgrafe G, Fotiadou EH (2012) TSH and thyrotropic agonists: key actors in thyroid homeostasis. J Thyroid Res.  https://doi.org/10.1155/2012/351864 Google Scholar
  12. Doufas AG, Mastorakos G (2000) The hypothalamic-pituitary-thyroid axis and the female reproductive system. Ann N Y Acad Sci 900:65–76CrossRefGoogle Scholar
  13. Fonseca TL et al (2013) Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Investig 123:1492–1500CrossRefGoogle Scholar
  14. Gerard NP, Bao L, Xiao-Ping H, Gerard C (1993) Molecular aspects of the tachykinin receptors. Regul Pept 43:21–35CrossRefGoogle Scholar
  15. Gitter BD, Regoli D, Howbert JJ, Glasebrook AL, Waters DC (1994) Interleukin-6 secretion from human astrocytoma cells induced by substance P. J Neuroimmunol 51:101–108CrossRefGoogle Scholar
  16. Günther T et al (2000) Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 406:199CrossRefGoogle Scholar
  17. Haschek WM, Rousseaux CG, Wallig MA, Bolon B, Ochoa R (2013) Haschek and Rousseaux’s handbook of toxicologic pathology. Academic Press, AmsterdamGoogle Scholar
  18. Hu G, He M, Ko WK, Lin C, Wong AO (2014) Novel pituitary actions of TAC3 gene products in fish model: receptor specificity and signal transduction for prolactin and somatolactin α regulation by neurokinin B (NKB) and NKB-related peptide in carp pituitary cells. Endocrinology 155:3582–3596CrossRefGoogle Scholar
  19. Kangawa K, Minamino N, Fukuda A, Matsuo H (1983) Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem Biophys Res Commun 114:533–540CrossRefGoogle Scholar
  20. Kopp P, Solis-S JC (2009) tHYRoID HoRMoNE clinical management of thyroid disease e-book. Elsevier, Philadelphia, p 19CrossRefGoogle Scholar
  21. Kouki T, Imai H, Aoto K, Eto K, Shioda S, Kawamura K, Kikuyama S (2001) Developmental origin of the rat adenohypophysis prior to the formation of Rathke’s pouch. Development 128:959–963Google Scholar
  22. Lecci A, Maggi C (2001) Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Pept 101:1–18CrossRefGoogle Scholar
  23. Lloyd RV, Buehler D, Khanafshar E (2011) Papillary thyroid carcinoma variants. Head Neck Pathol 5:51–56CrossRefGoogle Scholar
  24. Lu W, Xiong C, Zhang G, Huang Q, Zhang R, Zhang JZ, Li C (2009) Targeted photothermal ablation of murine melanomas with melanocyte-stimulating hormone analog–conjugated hollow gold nanospheres. Clin Cancer Res 15:876–886CrossRefGoogle Scholar
  25. Luo Y, Ishido Y, Hiroi N, Ishii N, Suzuki K (2014) The emerging roles of thyroglobulin. Adv Endocrinol.  https://doi.org/10.1155/2014/189194 Google Scholar
  26. Mandel SJ, Berry MJ, Kieffer JD, Harney JW, Warne RL, Larsen PR (1992) Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab 75:1133–1139Google Scholar
  27. McKenna NJ, O’Malley BW (2002) Minireview: nuclear receptor coactivators—an update. Endocrinology 143:2461–2465CrossRefGoogle Scholar
  28. Merchenthaler I, Maderdrut JL, O’Harte F, Conlon JM (1992) Localization of neurokinin B in the central nervous system of the rat. Peptides 13:815–829CrossRefGoogle Scholar
  29. Müller-Fielitz H et al (2017) Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun 8:484CrossRefGoogle Scholar
  30. Nakanishi S (1991) Mammalian tachykinin receptors. Annu Rev Neurosci 14:123–136CrossRefGoogle Scholar
  31. Noguchi Y, Harii N, Giuliani C, Tatsuno I, Suzuki K, Kohn LD (2010) Thyroglobulin (Tg) induces thyroid cell growth in a concentration-specific manner by a mechanism other than thyrotropin/cAMP stimulation. Biochem Biophys Res Commun 391:890–894CrossRefGoogle Scholar
  32. Norris DO, Carr JA (2013) Vertebrate endocrinology. Academic Press, AmsterdamGoogle Scholar
  33. Ooi GT, Tawadros N, Escalona RM (2004) Pituitary cell lines and their endocrine applications. Mol Cell Endocrinol 228:1–21CrossRefGoogle Scholar
  34. Pirahanchi Y, Jialal I (2018) Physiology, thyroid, stimulating hormone (TSH). In: StatPearls [Internet]. StatPearls Publishing, Treasure IslandGoogle Scholar
  35. Preedy VR, Burrow GN, Watson RR (2009) Comprehensive handbook of iodine: nutritional, biochemical, pathological and therapeutic aspects. Academic Press, AmsterdamGoogle Scholar
  36. Rance NE, Krajewski SJ, Smith MA, Cholanian M, Dacks PA (2010) Neurokinin B and the hypothalamic regulation of reproduction. Brain Res 1364:116–128CrossRefGoogle Scholar
  37. Rettori V, Milenkovic L, Fahim AM, Polak J, Bloom SR, McCann SM (1989) Role of neuromedin B in the control of the release of thyrotropin in the rat. Proc Natl Acad Sci 86:4789–4792CrossRefGoogle Scholar
  38. Rizos C, Elisaf M, Liberopoulos E (2011) Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J 5:76CrossRefGoogle Scholar
  39. Ross DS (2017) Diagnosis of hyperthyroidism UpToDate, Waltham, MA Accessed 20Google Scholar
  40. Samuels M (2000) Effects of metyrapone administration on thyrotropin secretion in healthy subjects–a clinical research center study. J Clin Endocrinol Metab 85:3049–3052Google Scholar
  41. Sarapura VD, Samuel MH (2017) Thyroid-stimulating hormone. The pituitary. Elsevier, Amsterdam, pp 163–201CrossRefGoogle Scholar
  42. Senese R, Cioffi F, de Lange P, Goglia F, Lanni A (2014) Thyroid: biological actions of ‘nonclassical’thyroid hormones. J Endocrinol 221:R1–R12CrossRefGoogle Scholar
  43. Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S (1990) Cloning and expression of a rat neuromedin K receptor cDNA. J Biol Chem 265:623–628Google Scholar
  44. Sinha RA, Singh BK, Yen PM (2014) Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends Endocrinol Metab 25:538–545CrossRefGoogle Scholar
  45. Steinhoff MS, von Mentzer B, Geppetti P, Pothoulakis C, Bunnett NW (2014) Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev 94:265–301CrossRefGoogle Scholar
  46. Topaloglu AK, Semple RK (2011) Neurokinin B signalling in the human reproductive axis. Mol Cell Endocrinol 346:57–64CrossRefGoogle Scholar
  47. True C, Nasrin Alam S, Cox K, Chan Y-M, Seminara SB (2015) Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology 156:1386–1397CrossRefGoogle Scholar
  48. Van Loy T, Vandersmissen HP, Poels J, Van Hiel MB, Verlinden H, Broeck JV (2010) Tachykinin-related peptides and their receptors in invertebrates: a current view. Peptides 31:520–524CrossRefGoogle Scholar
  49. Vargas-Uricoechea H, Bonelo-Perdomo A, Sierra-Torres CH (2014) Effects of thyroid hormones on the heart. Clínica e Investigación en Arteriosclerosis 26:296–309CrossRefGoogle Scholar
  50. Veenema AH, Blume A, Niederle D, Buwalda B, Neumann ID (2006) Effects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin. Eur J Neurosci 24:1711–1720CrossRefGoogle Scholar
  51. Wang F et al (2012) Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones. J Clin Endocrinol Metab 97:2724–2731CrossRefGoogle Scholar
  52. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B (2010) Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquat Toxicol 97:226–233CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Gomal Centre of Biochemistry and BiotechnologyGomal UniversityDera Ismail KhanPakistan
  2. 2.Institute of Basic Medical SciencesKhyber Medical UniversityPeshawarPakistan

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