Survivin as a Target for Anti-cancer Phytochemicals According to the Molecular Docking Analysis
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Survivin is a unique member of the inhibitor of apoptosis protein family. Research has approved Survivin’s ability to interact with Smac/DIABLO, suggesting that Survivin may suppress activation of caspases indirectly. On the other hand, research has demonstrated that many drugs for cancer therapy are unsuccessful and disappointing in advanced stages. Therefore, it is necessary to find new drugs with the highest anti-cancer properties and lowest side effects. We investigated the interaction of some phytochemicals with BIR domain of Survivin. In this study, the 3D structures of some phytochemicals, including Berberine, Carvacrol, Crocetin, Crocin, Curcumin, Picrocrocin, Piperine, and Thymol, were harnessed from Human Metabolome Database, which has reported some evidence about these phytochemicals’ anti-cancer effect via the apoptosis induction with Survivin. Then, these structures were prepared for molecular docking analysis by Autodock Vina software. Ultimately, the binding energies between docked Survivin and the above mentioned phytochemicals were calculated and their interactions were predicted. Our results indicated that all phytochemicals can interact with Survivin molecule in active site of Smac/DIABLO and the best minimum binding energies belong to Piperine and Picrocrocin. It is concluded that, out of the studied compounds, Piperine and Picrocrocin could act as potential inhibitors of Survivin.
KeywordsSurvivin Smac/DIABLO Inhibitors Autodock Vina Phytochemicals Berberine Piperine
This study was supported by Grant No 9775 from Shahroud University of Medical Sciences.
This study was funded by Shahroud University of Medical Sciences (Grant No 9775).
Compliance with Ethical Standards
Conflict of interest
All authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors. However, we have ethical cod approve IR.SHMU.REC.1397.112 by ethical committee of SHMU.
- Chen S et al (2015) Crocin inhibits cell proliferation and enhances cisplatin and pemetrexed chemosensitivity in lung cancer cells. Transl Lung Can Res 4:775–783. https://doi.org/10.3978/j.issn.2218-6751.2015.11.03 Google Scholar
- Dai W, Mu L, Cui Y, Li Y, Chen P, Xie H, Wang X (2019) Berberine promotes apoptosis of colorectal cancer via regulation of the long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2)/AU-binding factor 1 (AUF1)/B-Cell CLL/lymphoma 2 (Bcl-2) axis. Med Sci Monit 25:730–738. https://doi.org/10.12659/msm.912082 CrossRefGoogle Scholar
- Faridi N, Heidarzadeh H, Mohagheghi MA, Bathaie SZ (2019) BT-474 breast cancer cell apoptosis induced by crocin, a saffron carotenoid. Basic Clin Cancer Res 11:5–15Google Scholar
- Festuccia C, Colapietro A, Mancini A, D’alessandro A (2018) Crocetin and crocin from saffron in cancer chemotherapy and chemoprevention. Anti Cancer Agents Med Chem 19:38–47Google Scholar
- Gan R-Y (2012) Bioactivities of berberine: an Update, vol 1Google Scholar
- Global Burden of Disease Cancer C (2017) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study JAMA. Oncology 3:524–548. https://doi.org/10.1001/jamaoncol.2016.5688 Google Scholar
- Heidarzadeh H, Bathaie SZ, Abroun S, Mohagheghi MA (2018) Evaluating the cytotoxic effect of crocin on MDA-MB-468 cell line based on apoptosis induction, ER stress, and autophagy markers. Pathol Res 20:37–51Google Scholar
- Jafri A et al (2019) Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation. EXCLI J 18:154–164. https://doi.org/10.17179/excli2018-1928
- Kapellos G et al (2013) Overexpression of survivin levels in circulation and tissue samples of lung cancer patients. Anticancer Res 33:3475–3480Google Scholar
- Lu P, Lin H, Gu Y, Li L, Guo H, Wang F, Qiu X (2015) Antitumor effects of crocin on human breast cancer cells. Int J Clin Exp Med 8:20316–20322Google Scholar
- Mahmudabadi AZ, Karimi MM, Bahabadi M, Hoseinabadi ZB, JafariSani M, Ahmadi R (2016) Inhibition of AGS cancer cell proliferation following siRNA-mediated downregulation of VEGFR2. Cell J 18:381–388Google Scholar
- McCubrey JA et al. (2017) Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging 9:1477–1536. https://doi.org/10.18632/aging.101250
- Rothwell DG, Barzilay G, German M, Morera S, Freemont P, Hickson LD (1997) The structure and functions of the HAPl/Ref-1 protein. Oncol Res 9:275–280Google Scholar
- Sani MJ, Yazdi F, Karimi MM, Alizadeh J, Rahmati M, Mahmudabadi AZ (2016) The siRNA-mediated down-regulation of vascular endothelial growth factor receptor1. Iran Red Crescent Med J 18:381–388Google Scholar
- Sriwiriyajan S, Tedasen A, Lailerd N, Boonyaphiphat P, Nitiruangjarat A, Deng Y, Graidist P (2016) Anticancer and Cancer prevention effects of piperine-free Piper nigrum extract on N-nitrosomethylurea-induced mammary tumorigenesis in rats. Cancer Prev Res 9:74. https://doi.org/10.1158/1940-6207.capr-15-0127 CrossRefGoogle Scholar
- Yaffe PB, Power Coombs M, Doucette C, Walsh M, Hoskin D (2014) Piperine, an alkaloid from black pepper, inhibits growth of human colon cancer cells via G1 arrest and apoptosis triggered by endoplasmic reticulum stress. Mol Carcinogen 54:1070–1085. https://doi.org/10.1002/mc.22176 CrossRefGoogle Scholar
- Yu L, Li J, Xiao M (2018) Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON 23:1163–1168Google Scholar