Opioid Peptides: An Overview of Functional Significance

  • Jaspreet Kaur
  • Vikas KumarEmail author
  • Kartik Sharma
  • Sawinder Kaur
  • Yogesh Gat
  • Ankit Goyal
  • Beenu Tanwar


Bioactive peptides have been reported to exhibit opioid-like activity and are termed as opioid peptides. Either these are produced within the human body or they are derived from certain food sources (milk, cereals, vegetables, meat, poultry etc.), the former being endogenous opioid peptides and the latter are the exogenous opioid peptides. The opioid peptides perform a wide range of biological functions including neuromodulation, hormone-like function, analgesia, sedative effect, sleepiness, anti-hypertensive effect, ACE-inhibitory activity and many more. However, also possess adverse effects such as depressive effect, development of alcoholism, inflammation, apnea, autism and even death in rare cases. The effect of various processing methods and techniques on the opioid peptides requires further exploration. This is a unique and comprehensive review that will explore the opioid peptides, their types, sources, distribution and mechanism of action as well as the health effects.


Opioid peptides Endogenous and exogenous opioid peptides Mechanism of action Health effects 



The authors are thankful to Lovely Professional University for providing the necessary facilities, which were used for the preparation of manuscript.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Food Technology and Nutrition, School of AgricultureLovely Professional UniversityPhagwaraIndia
  2. 2.Department of Dairy ChemistryMansinhbhai Institute of Dairy and Food TechnologyMehsanaIndia
  3. 3.Department of Dairy TechnologyMansinhbhai Institute of Dairy and Food TechnologyMehsanaIndia

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