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Central Opioidergic and Adrenergic systems Mediates Food Intake via α1, α2 and β2 Receptors in Neonatal Layer-Type Chicken

  • Neda Nayebzadeh
  • Bita VazirEmail author
  • Morteza Zendehdel
  • Ahamd Asghari
Article
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Abstract

The aim of the current study was to determine possible interaction of central Opioidergic and Adrenergic systems on food intake regulation in neonatal layer-type chicken. In experiment 1, chicken ICV injected with control solution, DAMGO (µopioid receptors agonist, 125 pmol), parazosin (α1 receptor antagonist, 10 nmol) and DAMGO + parazosin. In experiment 2, control solution, DAMGO (125 pmol), yohimbine (α2 receptor antagonist, 13 nmol) and DAMGO + yohimbine were ICV injected. In experiment 3, FD3 birds ICV injected with control solution, DAMGO (125 pmol), metoprolol (β1 receptor antagonist, 24 nmol) and DAMGO + metoprolol. In experiment 4, FD3 chicks received ICV injection of control solution, DAMGO (125 pmol), ICI 118,551 (β2 receptor antagonist, 5 nmol) and DAMGO + ICI 118,551. Experiments 5–8 were similar to experiments 1–4, except chicken injected with DPDPE (δ opioid receptors agonist, 40 nmol) instead of DAMGO. Experiments 9–12 were similar to experiments 1–4, except chicken injected with U-50488H (κ opioid receptors agonist, 30 nmol) instead of DAMGO. Then, cumulative food intake was recorded at 30, 60 and 120 min after injection. According to the results, ICV injection of the DAMGO significantly decreased food intake while DPDPE and U-50488H significantly increased food intake in neonatal layer type chicken (P < 0.05). Co-injection of the DAMGO + ICI 118,551 decreased DAMGO-induced hypophagia (P < 0.05). Also, co-injection of the DPDPE + parazosin diminished hyperphagic effect of the DPDPE (P < 0.05). In addition, co-injection of the U-50488H + yohimbine diminished U-50488H-induced hyperphagia (P < 0.05). These results suggested there are interconnection between adrenergic and opioidergic systems on central food intake regulation which mediates via α1, α2 and β2 receptors in neonatal layer-type chicken.

Keywords

Opioidergic Adrenergic Food intake Layer-type chicken 

Notes

Acknowledgements

The authors thank the central laboratory (Dr. Rastegar Lab.) of the Faculty of Veterinary Medicine, University of Tehran for cooperation. This research is conducted as a part of the PhD thesis of the first author.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed Consent

This manuscript does not contain any studies with human subjects performed by any of the authors.

Research Involving Human and Animal Rights

All experiments were executed according to the Guide for the Care and Use of Laboratory Animals and were approved by the institutional animal ethics committee.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Neda Nayebzadeh
    • 1
  • Bita Vazir
    • 1
    Email author
  • Morteza Zendehdel
    • 2
  • Ahamd Asghari
    • 3
  1. 1.Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research BranchIslamic Azad UniversityTehranIran
  2. 2.Department of Basic Sciences, Faculty of Veterinary MedicineUniversity of TehranTehranIran
  3. 3.Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research BranchIslamic Azad UniversityTehranIran

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