Biological Properties, Current Applications and Potential Therapeautic Applications of Brevinin Peptide Superfamily

  • Fatemeh Zohrab
  • Saeedeh Askarian
  • Amin Jalili
  • Reza Kazemi OskueeEmail author


The Brevinin peptides are antimicrobial agents obtained from frog skin secretions. Brevinin-2R has attracted many attentions due to its very low hemolytic activity, cationic property, and high affinity to cancer cells. Moreover, it has shown little toxicity against normal mammalian cells, while having killed several tumor cell lines by activation of lysosome-mitochondrial death pathway. In this review, we introduced the Brevinin superfamily with a focus on its therapeutic applications. Next, some unique properties of Brevinins were briefly discussed, including their ability to stimulate insulin secretion, dendritic cell maturation, and wound healing. In this context, we also provide information about the decoration of nanoparticles, such as cerium nano-oxide, by Brevinins. Finally, we addressed their potential for anti-tumor and drug design applications.


Antimicrobial peptide Brevinin Bioactive peptide Cancer Frog skin secretions 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

The article does not contain any studies with human participants or with animals performed by any of the authors.

Informed Consent

The article is a review manuscript and does not contain any photograph. However, the figures and tables are also prepared by the authors themselves.


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Authors and Affiliations

  1. 1.Department of Medical Biotechnology, Faculty of MedicineMashhad University of Medical SciencesMashhadIran
  2. 2.Torbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran
  3. 3.Neurogenic Inflammation Research CenterMashhad University of Medical SciencesMashhadIran

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