Journal of Sol-Gel Science and Technology

, Volume 89, Issue 2, pp 531–542 | Cite as

In situ mucoadhesive hydrogel based on methylcellulose/xyloglucan for periodontitis

Graphical Abstract
  • Namon Hirun
  • Vimon TantishaiyakulEmail author
  • Tanatchaporn Sangfai
  • Passaporn Ouiyangkul
  • Lin Li
Original Paper: Sol–gel and hybrid materials for biological and health (medical) applications


Novel hydrogels of 5, 6, and 7% w/v of methylcellulose (5MC, 6MC, and 7MC) with 1.5% w/v of tamarind seed xyloglucan (TSX) were developed via an in situ gel forming process. The MC and MC/TSX solutions formed two gel types: a soft gel and a turbid hard gel respectively upon heating. These samples were characterized using a test-tube-tilting method (TTM), rheological, and turbidity measurements. The interactions and the mechanism of gelation were studied using ATR-FTIR. The release of metronidazole (MTZ) from the hydrogels was also investigated. Based on the TTM results, 6MC/TSX, 7MC, and 7MC/TSX were solution at room temperature but could form gel at body temperature. ATR-FTIR demonstrated stronger hydrophobic associations of MC in the turbid gel than in the soft gel which corresponded to the higher intensity of the C–O band of MC. The peak intensity was greater in the presence of TSX, reflecting the role of TSX to increase hydrophobicity and decrease gelation temperature of MC. SEM revealed a microporous morphology of 6MC/TSX, 7MC, and 7MC/TSX and the pore size of the soft gel was greater than that of the turbid gel. The high relative rheological synergism at 37 °C indicated a high mucoadhesive property of the MC/TSX hydrogels. MC and MC/TSX exhibited a suitable syringeability to ease of administration at 25 °C. MTZ exhibited a more sustained release from 7MC/TSX than from a commercial formulation. Therefore, 7MC/TSX hydrogel could be potentially used for the in situ delivery of MTZ for the treatment of periodontitis.


  • Novel MC/TSX hydrogels were developed for in situ delivery of a drug.

  • MC/TSX formed soft and turbid gels at body and higher temperatures, respectively.

  • Increasing hydrophobicity by TSX facilitated the gelation of MC in the blend.

  • MC/TSX soft gel was highly mucoadhesive and showed suitable syringeability.


Xyloglucan Methylcellulose Mucoadhesion Soft gel Turbid gel 



This work was supported by Office of the Higher Education Commission, through its program of Center of Excellence Network and Prince of Songkla University Strategic Research Project (Grant no. PHA610372S).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10971_2018_4878_MOESM1_ESM.pdf (414 kb)
Supplemental Figure


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Namon Hirun
    • 1
  • Vimon Tantishaiyakul
    • 2
    • 3
    Email author
  • Tanatchaporn Sangfai
    • 1
  • Passaporn Ouiyangkul
    • 3
  • Lin Li
    • 4
  1. 1.School of PharmacyWalailak UniversityNakhon Si ThammaratThailand
  2. 2.Drug Delivery System Excellence Center, Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-YaiThailand
  3. 3.Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-YaiThailand
  4. 4.School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

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