Surfactant-assisted sol–gel synthesis and characterization of hierarchical nanoporous merwinite with controllable drug release
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The aim of this research is to suggest both new and efficient synthesis method for preparation of pure phase nanoporous merwinite ((Ca3Mg(SiO4)2), NM) bioceramics and assess their in vitro drug delivery potential. Surfactant-assisted sol–gel method is used to produce NM using cetyltrimethylammoniumbromide (CTAB) as a surfactant agent. The XRD results showed that a single-phase merwinite is obtained after calcination at 850 °C. Both the FESEM and N2 adsorption desorption results exhibited that the samples have hierarchical porous structure ranging from 25 nm to 3.5 μm. Potential application of the synthesized calcium-magnesium-silicate samples as a drug delivery agent is studied by estimating their ibuprofen release properties up to 180 h. This study revealed that NM is produced by surfactant-assisted sol–gel method at lower calcination temperature compared to other studies and the synthesized samples can be used as a promising local drug delivery system.
In this study, for the first time a simple and efficient strategy is developed to synthesize both nanoporous and pure phase merwinite as a new local drug delivery system.
The results showed that single-phase nanoporous merwinite was synthesized by surfactant-assisted sol-gel method.
Nanoporous samples had a hierarchical porous structure ranging from 25 nm to 3.5 μm.
Samples showed sustained drug release up to 180 h and could be used as a promising drug delivery system.
KeywordsMerwinite Sol–gel method Sustained release Ibuprofen
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Conflict of interest
The authors declare that they have no conflict of interest.
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