Journal of Sol-Gel Science and Technology

, Volume 89, Issue 1, pp 78–90 | Cite as

Engineering of large-pore lipid-coated mesoporous silica nanoparticles for dual cargo delivery to cancer cells

  • Achraf Noureddine
  • Elizabeth A. Hjelvik
  • Jonas G. Croissant
  • Paul N. Durfee
  • Jacob O. Agola
  • C. Jeffrey BrinkerEmail author
Brief Communication: Sol-gel, hybrids and solution chemistries


Lipid-coated mesoporous silica nanoparticles (LC-MSNs) have recently emerged as a next-generation cargo delivery nanosystem combining the unique attributes of both the organic and inorganic components. The high surface area biodegradable inorganic mesoporous silica core can accommodate multiple classes of bio-relevant cargos in large amounts, while the supported lipid bilayer coating retains the cargo and increases the stability of the nanocarrier in bio-relevant media which should promote greater bio-accumulation of LC-MSNs in cancer sites. In this contribution, we report on the optimization of various sol–gel synthesis (pH, stirring speed) and post-synthesis (hydrothermal treatment) procedures to enlarge the MSN pore size and tune the surface chemistry so as to enable loading and delivery of large biomolecules. The proof of concept of the dual cargo-loaded nanocarrier has been demonstrated in immortalized cervical cancer HeLa cells using MSNs of various fine-tuned pore sizes.


  • Lipid-coated mesoporous silica nanoparticles were prepared for dual cargo delivery to cancer cells.

  • The pore and particle sizes, surface areas, and condensation degrees were tuned by sol–gel processes.

  • Sol–gel (pH, stirring speed) and post-synthesis (hydrothermal treatment) parameters were optimized.


Mesoporous silica nanoparticles Large pore Sol–gel Supported lipid bilayer Drug delivery Biomedical 



This work was supported by the Sandia National Laboratories' Laboratory Directed Research and Development (LDRD) program and the Lymphoma and Leukemia Society (LLS) (A.N., E.A.H., J.G.C., P.N.D., J.O.A. and C.J.B.). Sandia National Laboratories is a multimission laboratory managed and operated by National Technology & Engineering Solutions of Sandia, LLC, a wholly owned subsidiary of Honeywell International Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525. This paper describes objective technical results and analysis. Any subjective views or opinions that might be expressed in the paper do not necessarily represent the views of the U.S. Department of Energy or the United States Government.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Achraf Noureddine
    • 1
  • Elizabeth A. Hjelvik
    • 1
  • Jonas G. Croissant
    • 1
  • Paul N. Durfee
    • 1
  • Jacob O. Agola
    • 1
  • C. Jeffrey Brinker
    • 1
    • 2
    Email author
  1. 1.Chemical and Biological EngineeringUniversity of New MexicoAlbuquerqueUSA
  2. 2.Center for Micro-Engineered Materials, Advanced Materials LaboratoryUniversity of New MexicoAlbuquerqueUSA

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