A simple decontamination procedure for unintended iodide impurity during [11C]methionine production
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A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [11C]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [11C]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [11C]methionine solution using an anion-exchange resin cartridge.
KeywordsL-[S-methyl-11C]methionine Iodine impurity [11C]Radiopharmaceuticals Anion-exchange resin cartridge
We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).
- 5.Tang G-H, Wang M-F, Tang X-L, Luo L, Gan M-Q (2004) Automated synthesis of (S-[11C]-methyl)-l-methionine and (S-[11C]-methyl)-l-cysteine by on-column [11C]methylation. J Nucl Radiochem 26:77–83Google Scholar
- 7.Lodi F, Rizzello A, Trespidi S, Di Pierro D, Marengo M, Farsad M, Fanti S, Al-Nahhas A, Rubello D, Boschi S (2008) Reliability and reproducibility of N-[11C]methyl-choline and L-(S-methyl-[11C])methionine solid-phase synthesis: a useful and suitable method in clinical practice. Nucl Med Commun 29:736–740CrossRefGoogle Scholar
- 9.Quincoces G, Lopez-Sanchez L, Sanchez-Martınez M, Rodrıguez-Fraile M, Penuelas I (2010) Design and performance evaluation of single-use whole-sterile “plug & play” kits for routine automated production of [11C]choline and [11C]methionine with radiopharmaceutical quality. Appl Radiat Isot 68:2298–2301CrossRefGoogle Scholar
- 14.Sodium iodide (2019). http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+750. Accessed 30 Aug 2019