Advertisement

A simple decontamination procedure for unintended iodide impurity during [11C]methionine production

  • Hyun Sik Park
  • Byung Seok MoonEmail author
  • Hong Jin Lee
  • Hyun Ho An
  • Bom Sahn Kim
  • Won Woo Lee
  • Sang Eun Kim
  • Byung Chul LeeEmail author
Article
  • 11 Downloads

Abstract

A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [11C]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [11C]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [11C]methionine solution using an anion-exchange resin cartridge.

Keywords

L-[S-methyl-11C]methionine Iodine impurity [11C]Radiopharmaceuticals Anion-exchange resin cartridge 

Notes

Acknowledgements

We thank Yoo Jin Jung and Byoung Min Jo for their technical assistance and this research was supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C-0947), and the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, Republic of Korea (NRF-2018R1D1A1A02085705 and 2015R1C1A1A02037284).

References

  1. 1.
    Maffione AM, Nanni C, Ambrosini V, Trespidi S, Lopci E, Allegri V, Castellucci P, Montini G, Boschi S, Fanti S (2009) 11C-Methionine PET/CT in central nervous system tumors: a review. Curr Radiopharm 2:160–164CrossRefGoogle Scholar
  2. 2.
    Watanabe A, Muragaki Y, Maruyama T, Shinoda J, Okada Y (2016) Usefulness of 11C-methionine position emission tomography for treatment-decision making in cases of non-enhancing glioma-like brain lesions. J Neuro-Oncol 126:577–583CrossRefGoogle Scholar
  3. 3.
    Glaudemans AWJM, Enting RH, Heesters MAAM, Dierckx RAJO, van Rheenen RWJ, Walenkamp AME, Slart RHJA (2013) Value of 11C-methionine PET in imaging brain tumours and metastases. Eur J Nucl Med Mol Imaging 40:615–635CrossRefGoogle Scholar
  4. 4.
    Pascali C, Bogni A, Iwata R, Decise D, Crippa F, Bombardieri E (1999) High efficiency preparation of L-[S-methyl-11C]methionine by on-column [11C]methylation on C18 Sep-Pak. J Label Compd Radiopharm 42:715–724CrossRefGoogle Scholar
  5. 5.
    Tang G-H, Wang M-F, Tang X-L, Luo L, Gan M-Q (2004) Automated synthesis of (S-[11C]-methyl)-l-methionine and (S-[11C]-methyl)-l-cysteine by on-column [11C]methylation. J Nucl Radiochem 26:77–83Google Scholar
  6. 6.
    Lodi F, Trespidi S, Di Pierro D, Marengo M, Farsad M, Fanti S, Franchi R, Boschi S (2007) A simple Tracerlab module modification for automated on-column [11C]methylation and [11C]carboxylation. Appl Radiat Isot 65:691–695CrossRefGoogle Scholar
  7. 7.
    Lodi F, Rizzello A, Trespidi S, Di Pierro D, Marengo M, Farsad M, Fanti S, Al-Nahhas A, Rubello D, Boschi S (2008) Reliability and reproducibility of N-[11C]methyl-choline and L-(S-methyl-[11C])methionine solid-phase synthesis: a useful and suitable method in clinical practice. Nucl Med Commun 29:736–740CrossRefGoogle Scholar
  8. 8.
    Cheung M-K, Ho C-L (2009) A simple, versatile, low-cost and remotely operated apparatus for [11C]acetate, [11C]choline, [11C]methionine and [11C]PIB synthesis. Appl Radiat Isot 67:581–589CrossRefGoogle Scholar
  9. 9.
    Quincoces G, Lopez-Sanchez L, Sanchez-Martınez M, Rodrıguez-Fraile M, Penuelas I (2010) Design and performance evaluation of single-use whole-sterile “plug & play” kits for routine automated production of [11C]choline and [11C]methionine with radiopharmaceutical quality. Appl Radiat Isot 68:2298–2301CrossRefGoogle Scholar
  10. 10.
    Pascali C, Bogni A, Cucchi C, Laera L, Crispu O, Maiocchi G, Crippa F, Bombardieri E (2011) Detection of additional impurities in the UV-chromatogram of L-[S-methyl-11C]methionine. J Radioanal Nucl Chem 288:405–409CrossRefGoogle Scholar
  11. 11.
    Bogni A, Bombardieri E, Iwata R, Cadini L, Pascali C (2003) Stability of L-[S-methyl-11C]methionine solutions. J Radioanal Nucl Chem 256:199–203CrossRefGoogle Scholar
  12. 12.
    Moon BS, Lee HJ, Lee WK, Hur MG, Yang SD, Lee BC, Kim SE (2015) Development of additive [11C]CO2 target system in the KOTRON-13 cyclotron and its application for [11C]radiopharmaceutical production. Nucl Instrum Methods Phys Res B 356–357:1–7CrossRefGoogle Scholar
  13. 13.
    Kilian K, Pekal A, Juszczyk J (2016) Synthesis of 11C-methionine through gas phase iodination using Synthra MeI Plus synthesis module. Nukleonika 61:29–33CrossRefGoogle Scholar
  14. 14.

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  • Hyun Sik Park
    • 1
  • Byung Seok Moon
    • 2
    Email author
  • Hong Jin Lee
    • 1
  • Hyun Ho An
    • 1
  • Bom Sahn Kim
    • 2
  • Won Woo Lee
    • 1
  • Sang Eun Kim
    • 1
    • 3
    • 4
  • Byung Chul Lee
    • 1
    • 3
    Email author
  1. 1.Department of Nuclear MedicineSeoul National University Bundang Hospital, Seoul National University College of MedicineSeongnamRepublic of Korea
  2. 2.Department of Nuclear MedicineEwha Womans University Seoul Hospital, Ewha Womans University College of MedicineSeoulRepublic of Korea
  3. 3.Center for Nanomolecular Imaging and Innovative Drug DevelopmentAdvanced Institutes of Convergence TechnologySuwonRepublic of Korea
  4. 4.Department of Transdisciplinary Studies, Graduate School of Convergence Science and TechnologySeoul National UniversitySeoulRepublic of Korea

Personalised recommendations