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Journal of Radioanalytical and Nuclear Chemistry

, Volume 322, Issue 2, pp 1079–1083 | Cite as

Neutron activation analysis as a tool for tracing the accumulation of silver nanoparticles in tissues of female mice and their offspring

  • Inga ZinicovscaiaEmail author
  • Dmitrii Grozdov
  • Nikita Yushin
  • Alexandra Ivlieva
  • Elena Petritskaya
  • Dmitriy Rogatkin
Article
  • 35 Downloads

Abstract

The silver accumulation in different tissues of female mice and their offspring after prolonged oral administration of silver nanoparticles to the females during pregnancy and lactation was investigated. Silver content in different organs (blood, liver, brain, kidney and lungs) was determined by means of neutron activation analysis. According to the obtained data silver nanoparticles are able to reach and cross the placental barrier and blood-to-brain barrier in both mice female and their offspring. In mice female the highest silver concentration was determined in lungs, followed by brain, liver, kidney and blood. In offspring silver bioaccumulation changed in the following order lungs > brain > blood > liver > kidney. The average specific mass content of silver which crossed the blood–brain barrier was 373 ± 75 ng (for female) and 385 ± 57 ng (for offspring). The obtained results are important for studies in developmental and reproductive toxicity of nanomaterials.

Keywords

Silver nanoparticles Brain Liver Lungs Kidney Blood Mice Offspring Distribution Neutron activation analysis 

Notes

Acknowledgements

This work was supported by the Russian Foundation for Basic Research (RFBR) [Grant No. 19-015-00145 A].

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The experiments involving mice had been approved by local Ethics Committee and met the requirements of the Directive 2010/63/EU of the European Parliament and of the Council from September 22, 2010 on protection of animals used for scientific purposes and in compliance with the American College of Toxicology Policy on the Use of Animals in Toxicology.

References

  1. 1.
    Yang H, Sun C, Fan Z et al (2012) Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy. Sci Rep 2:847CrossRefGoogle Scholar
  2. 2.
    Campagnolo L, Massimiani M, Vecchione L et al (2017) Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus. Nanotoxicology.  https://doi.org/10.1080/17435390.2017.1343875 CrossRefPubMedGoogle Scholar
  3. 3.
    Takeda K, Suzuki K, Ishihara A et al (2009) Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55:95–102CrossRefGoogle Scholar
  4. 4.
    Morishita Y, Yoshioka Y, Takimura Y et al (2016) Distribution of silver nanoparticles to breast milk and their biological effects on breast-fed offspring mice. ACS Nano.  https://doi.org/10.1021/acsnano.6b01782 CrossRefPubMedGoogle Scholar
  5. 5.
    Recordati C, De Maglie M, Bianchessi S et al (2016) Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects. Part Fibre Toxicol 13:12CrossRefGoogle Scholar
  6. 6.
    Sweeney S, Adamcakova-Dodd A, Thorne PS, Assouline JG (2018) Multifunctional nanoparticles for real-time evaluation of toxicity during fetal development. PLoS ONE.  https://doi.org/10.1371/journal.pone.0192474 CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Chu M, Wu Q, Yang H et al (2010) Transfer of quantum dots from pregnant mice to pups across the placental barrier. Small 6:670–678CrossRefGoogle Scholar
  8. 8.
    Yamashita K, Yoshioka Y, Higashisaka K et al (2011) Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol 6:321–328CrossRefGoogle Scholar
  9. 9.
    Semmler-Behnke M, Kreyling WG, Lipka J et al (2008) Biodistribution of 1.4- and 18-nm gold particles in rats. Small 4:2108–2111CrossRefGoogle Scholar
  10. 10.
    Sharma A, Cornejo C, Mihalic J et al (2018) Physical characterization and in vivo organ distribution of coated iron oxide nanoparticles. Sci Rep 8:4916CrossRefGoogle Scholar
  11. 11.
    Sadauskas E, Wallin H, Stoltenberg M et al (2007) Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol 4:10CrossRefGoogle Scholar
  12. 12.
    Aengenheister L, Dietrich D, Sadeghpour A et al (2018) Gold nanoparticle distribution in advanced in vitro and ex vivo human placental barrier models. J Nanobiotechnol 16:79CrossRefGoogle Scholar
  13. 13.
    Lasagna-Reeves C, Gonzalez-Romero D, Barria MA et al (2010) Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochem Biophys Res Commun 393:649–655CrossRefGoogle Scholar
  14. 14.
    Perez-Jordan MY, Soldevila J, Salvador A et al (1998) Inductively coupled plasma mass spectrometry analysis of wines. J Anal At Spectrom 13:33–39Google Scholar
  15. 15.
    De Jong WH, Hagens WI, Krystek P et al (2008) Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29:1912–1919CrossRefGoogle Scholar
  16. 16.
    Frontasieva MV (2011) Neutron activation analysis in the life sciences. PEPAN 42:332–378.  https://doi.org/10.1134/S1063779611020043 CrossRefGoogle Scholar
  17. 17.
    The methodological recommendations for euthanasia of small pet animals. https://www.kostromavet.ru/files/files/Evtanaziy_09_06_14.pdf. Accessed 15 Aug 2019 (in Russian)
  18. 18.
    Zinicovscaia I, Pavlov SS, Frontasyeva MV et al (2018) Accumulation of silver nanoparticles in mice tissues studied by neutron activation analysis. J Radioanal Nucl Chem 318:985–989CrossRefGoogle Scholar
  19. 19.
    Greenberg RR, Bode P, De Nadai Fernandes EA (2011) Neutron activation analysis: a primary method of measurement. Rev Spectrochim Acta Part B 66:193–241CrossRefGoogle Scholar
  20. 20.
    Pavlov SS, Dmitriev AYu, Frontasyeva MV (2016) Automation system for neutron activation analysis at the reactor IBR-2, Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russia. J Radioanal Nucl Chem 309:27–38CrossRefGoogle Scholar
  21. 21.
    Valentini X, Rugira P, Frau A et al (2019) Hepatic and renal toxicity induced by TiO2 nanoparticles in rats: a morphological and metabonomic study. J Toxicol 2019:5767012CrossRefGoogle Scholar
  22. 22.
    Lee Y, Choi J, Kim P et al (2012) A transfer of silver nanoparticles from pregnant rat to offspring. Toxicol Res 28:139–141CrossRefGoogle Scholar
  23. 23.
    Du B, Yu M, Zheng J (2018) Transport and interactions of nanoparticles in the kidneys. Nat Rev Mater 3:358–374CrossRefGoogle Scholar
  24. 24.
    Purves D, Augustine GJ, Fitzpatrick D, Katz LC, La Mantia AS, McNamara JO, Williams SM (2001) Neuroscience, 2nd edn. Sinauer Associates, SunderlandGoogle Scholar
  25. 25.
    Antsiferova AA, Buzulukov YuP, Demin VA et al (2015) Radiotracer methods and neutron activation analysis for the investigation of nanoparticle biokinetics in living organisms. Nanotechnol Russ 10:101–108CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.Frank Laboratory of Neutron PhysicsJoint Institute for Nuclear ResearchDubnaRussian Federation
  2. 2.Horia Hulubei National Institute for R&D in Physics and Nuclear EngineeringBucharest, MagureleRomania
  3. 3.M.F. Vladimirskiy Moscow Regional Research and Clinical InstituteMoscowRussian Federation

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