Skip to main content
SpringerLink
Log in

Radioactive iodine volatilization inhibition effect of cyclodextrin

  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The radioactive iodine volatilization inhibition of cyclodextrin and the influence of radiation on this effect were evaluated by observing the change in the radioactive iodine-131 (131I) retention rate in an aqueous solution containing cyclodextrin as a function of time. The retention rate was found to be 1/3–1/4 that of an aqueous solution without cyclodextrin. The 131I retention rates remained consistent even after exposure to high doses of radiation up until 30,000 Gy. Cyclodextrin was thus found to be effective for inhibiting the volatilization of radioactive iodine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Japan Radioisotope Association (2018) Statistics on the distribution of radioisotopes in Japan 2017. Japan Radioisotope Association, Tokyo

  2. Hirota M, Higaki S, Higaki T, Hasezawa S (2013) Investigation of contamination in spinach collected immediately following the Fukushima Daiichi nuclear disaster. Radiat Saf Manag 12:43–47

    Article  Google Scholar 

  3. J-PARC (2013) 3rd Accelerator facility accident report to nuclear regulation authority. http://j-parc.jp/ja/topics/HDAccident20130812_01.pdf. Accessed 2 Apr 2019 (in Japanese)

  4. ICRP Publication 66 (1994) Human respiratory tract model for radiological protection. Ann ICRP 24:1–3

    Article  Google Scholar 

  5. ICRP Publication 67 (1993) Age-dependent doses to members of the public from intake of radionuclides-Part 2 ingestion dose coefficients. Ann ICRP 23:3–4

    Google Scholar 

  6. Nishizawa K (2009) Technical guideline on radioactive iodine safety management. Jpn J Radiat Saf Manag 8:64–85 (in Japanese)

    Google Scholar 

  7. Nishizawa K (2009) Technical guideline on radioactive iodine safety management Part 2. Jpn J Radiat Saf Manag 8:149–186 (in Japanese)

    Google Scholar 

  8. Wada K (2011) Characteristics and utilization of cyclodextrin derivatives-Mainly on hydroxypropyl-β-cyclodextrin. Bull Appl Glycosci 1:322–326 (in Japanese)

    Article  CAS  Google Scholar 

  9. Szente L, Fenyvesi É, Szejtli J (1999) Entrapment of iodine with cyclodextrins: potential application of cyclodextrins in nuclear waste management. Environ Sci Technol 33:4495–4498

    Article  CAS  Google Scholar 

  10. Ueda H (1992) Possible use of cyclodextrin in pharmaceutical preparations. Proc Hoshi Univ 34:1–12 (in Japanese)

    CAS  Google Scholar 

  11. Lechat FL, Wouessidjewe D, Herrenknecht C, Duchěne D (1992) Preparation and stability of iodine/a-cyclodextrin inclusion complex. Drug Dev Ind Pharm 18:1853–1863

    Article  Google Scholar 

  12. Polumbryk M, Pasichnyi V, Omelchenko C, Vyshnevskiy O (2017) Determination of structure and morphology of the cyclodextrins-iodine complexes. Ukr Food J 6:117–124

    Article  CAS  Google Scholar 

  13. WHO Cicad No. 72 (2009) Iodine and inorganic iodides: human health aspects. World Health Organization, Geneva

    Google Scholar 

  14. Watanabe N, Yokoyama K, Kinuya S, Shuke N, Shimizu M, Futatsuya R, Michigishi T, Tonami N, Seto H, Goodwin DA (1998) Radiotoxicity after iodine-131 therapy for thyroid cancer using the micronucleus assay. J Nucl Med 39:436–440

    CAS  PubMed  Google Scholar 

  15. Majima H et al (1984) Encyclopedia nipponica. Shogakukan, Tokyo (In Japanese)

    Google Scholar 

  16. Tokyo Electric Power Company (2011) TEPCO Press Release. http://www.tepco.co.jp/en/press/corp-com/release/betu11_e/images/110327e15.pdf. Accessed 2 Apr 2019

  17. Science and Technology Agency (2000) Notice of the Science and Technology Agency, No. 5; Specifying Standards for the Quantities, etc. of Radiation-Emitting Isotopes (Last revised: Public Notice of the Ministry of Education, Culture, Sports, Science and Technology, No. 58, March 29, 2013)

Download references

Acknowledgements

This work was supported by the Japan Society for the Promotion of Science (JSPS) through a Grant-in-Aid for Scientific Research (C) (No. 15K00581). We are also grateful to Shinshu University and The University of Tokyo for providing the laboratory and to CycloChem Bio Co., Ltd. for providing us with several cyclodextrin samples.

Author information

Authors and Affiliations

  1. Research Center for Supports to Advanced Sciences, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Masahiro Hirota

  2. Isotope Science Center, The University of Tokyo, 2-11-16 Yayoi Bunkyo-ku, Tokyo, 113-0032, Japan

    Shogo Higaki

  3. Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji Chuo-ku, Kumamoto, 862-0976, Japan

    Shigeki Ito

  4. CycloChem Bio Co., Ltd., 7-4-5 Minamicho Minatoshima Chuo, Kobe, 650-0047, Japan

    Yoshiyuki Ishida & Keiji Terao

Authors
  1. Masahiro Hirota
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shogo Higaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shigeki Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiyuki Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Keiji Terao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masahiro Hirota.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hirota, M., Higaki, S., Ito, S. et al. Radioactive iodine volatilization inhibition effect of cyclodextrin. J Radioanal Nucl Chem 320, 621–625 (2019). https://doi.org/10.1007/s10967-019-06504-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10967-019-06504-x

Keywords

Search

Navigation