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Journal of Radioanalytical and Nuclear Chemistry

, Volume 319, Issue 1, pp 453–458 | Cite as

Stability evaluation of Tc-99m radiolabeled GRPr antagonist with amino acid chelators

  • Zhengkun Zhong
  • Wentao KanEmail author
  • Wei Liao
Article
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Abstract

In order to select a chelator with excellent stability, easier radiolabeling process and low cost, GRPr antagonist RM26 with the amino acid based chelator was radiolabeled with technetium-99m. The stability of the radiolabeled peptides in PBS, serum as well as in the presence of excess cysteine was compared.

Keywords

Technetium-99m Radiopeptide RM26 KGC N3S 
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Notes

Acknowledgements

This research is financially supported by Science and Technology Development of Foundation of China Academy of Engineering Physics (2014A0301011) and China National Natural Science Foundation (21571164).

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  1. 1.Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyangChina

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