Role of diet and trace elements in lithogenesis of renal calculi
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Twenty eight stones were characterized for chemical composition and structure. The concentrations of trace elements were determined using INAA while EDXRF was used for determining the calcium contents of the stones. Twenty stones were found to be mainly composed of calcium, six were mixed type and the remaining two were of uric acid type. The concentrations of trace elements namely Zn, Sr, Fe and Cr were lower in uric acid stones as compared to calcium based stones. Diet analysis of 310 patients who were treated for renal stones showed a diet rich in calcium and oxalate and decreased water consumption.
KeywordsTrace elements Lithogenesis Renal calculi Neutron activation analysis EDXRF
The authors thank the operating staff of Dhruva Reactor, Bhabha Atomic Research Centre, Mumbai for their cooperation in the irradiation of samples. One of the authors (AS) would like to place in record his special thanks to University Grants Commission and Department of Atomic Energy of the Government of India for providing him financial support under the Consortium for Scientific Research Scheme Project M-169 to carry out the study on renal stones reported in the present work and to Panjab University, Chandigarh for granting sabbatical leave and duty leave to go to USA to carry and finish the outlined research work. The guidance of Dr. R. Acharya, Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai and Dr. A.V.R. Reddy, Analytical Chemistry Division, Bhabha Atomic Research Centre, Mumbai in the formulation and implementation of the project is duly acknowledged. The authors would also like to thank the staff of Central Instrumentation Laboratory of Panjab University, Chandigarh for carrying out the XRD and FTIR based measurements. Authors also thank Dr. P.D. Naik, Associate Director, Chemistry Group and Head, Analytical Chemistry Division, Bhabha Atomic Research Centre, Mumbai and Dr. V. Siruguri, Centre Director, UGC-DAE Consortium for Scientific Research, Mumbai for their support.
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