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Accumulation of silver nanoparticles in mice tissues studied by neutron activation analysis

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Abstract

For estimation of toxicity of silver nanoparticles under long-term exposure for mammals and humans, the accumulation of silver in mice tissues (blood, liver, brain) during 2 and 4 months experiments was examined. Neutron activation analysis revealed silver in all examined tissues with its highest concentrations in liver followed by brain (including silver in blood vessels). The lowest concentration of silver was observed in blood samples. The mean specific mass content of silver which crossed the blood–brain barrier was 225 ± 99 ng (for male) and 395 ± 150 ng (for female) of the brain sample after 2 months of administration, 860 ± 200 ng (for male) and 880 ± 200 ng (for female) of brain sample after 4 months of administration. The obtained results are of great importance for nanotoxicological studies.

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Authors and Affiliations

  1. Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, Russian Federation, 141980

    Inga Zinicovscaia, Sergey S. Pavlov & Marina V. Frontasyeva

  2. Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Bucharest, Magurele, Romania

    Inga Zinicovscaia

  3. Moscow Regional Research and Clinical Institute named after M. F. Vladimirskiy, Moscow, Russia, 129110

    Alexandra L. Ivlieva, Elena N. Petritskaya & Dmitriy A. Rogatkin

  4. National Research Centre «Kurchatov Institute», Ploshchad’ Akademika Kurchatova, Moscow, Russian Federation

    Vyacheslav A. Demin

Authors
  1. Inga Zinicovscaia
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  2. Sergey S. Pavlov
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  3. Marina V. Frontasyeva
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  4. Alexandra L. Ivlieva
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  5. Elena N. Petritskaya
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  6. Dmitriy A. Rogatkin
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  7. Vyacheslav A. Demin
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Correspondence to Inga Zinicovscaia.

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Zinicovscaia, I., Pavlov, S.S., Frontasyeva, M.V. et al. Accumulation of silver nanoparticles in mice tissues studied by neutron activation analysis. J Radioanal Nucl Chem 318, 985–989 (2018). https://doi.org/10.1007/s10967-018-6193-6

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  • DOI: https://doi.org/10.1007/s10967-018-6193-6

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