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A fluorescent Zn(II)-containing coordination polymer for antibiotic sensing and treatment activity on periodontal tissue inflammation after orthodontics by inhibiting the growth of Porphyromonas gingivalis

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A novel fluorescent zinc(II)-containing coordination polymer {[Zn(DIPT)](NO3)(H2O)3} (1) having the channel-type framework was generated via using rigid three-terminal nitrogenous hetero-ligand 5-(3,5-di(1H-imidazol-1-yl)phenyl)-2H-tetrazole (HDIPT) in solvent thermal reaction. Benefitting from its excellent fluorescent emission along with high water stability, complex 1 shows selective luminescence sensing for sulfonamide antibiotics with high sensitivity in water. In addition, the anti-bacterial activity of compound 1 against Porphuromonas gingivalis (P. gingivalis ATCC 33277) in vitro and in vivo was evaluated. Firstly, the growth curves of P. gingivalis ATCC 33277 was measured after compound 1 treatment for the in vitro activity evaluation. Then, the in vivo protective effect of compound 1 was further explored, the IL-8 and TNF-α level in gingival fluid revealed the excellent inhibitory effect of compound 1 on the inflammatory response. The results acquired via pose scoring software as well as molecular docking indicated that the compound 1 might bind and inhibit the NF-κB protein function, this might provide a latent regulatory mechanism for compound 1.

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Correspondence to Fengchun Hou.

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Niu, S., Zhang, Q., Zang, Y. et al. A fluorescent Zn(II)-containing coordination polymer for antibiotic sensing and treatment activity on periodontal tissue inflammation after orthodontics by inhibiting the growth of Porphyromonas gingivalis. J Polym Res 27, 58 (2020). https://doi.org/10.1007/s10965-020-2010-3

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  • Coordination polymer
  • Fluorescent CP
  • Antibiotic sensing
  • Anti-bacterial
  • Molecular docking