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Journal of Polymer Research

, 26:212 | Cite as

pH-responsive smart gels of block copolymer [pluronic F127-co-poly(acrylic acid)] for controlled delivery of Ivabradine hydrochloride: its toxicological evaluation

  • Natasha Nasir
  • Mahmood AhmadEmail author
  • Muhammad Usman Minhas
  • Kashif Barkat
  • Muhammad Farooq Khalid
ORIGINAL PAPER
  • 25 Downloads

Abstract

Pluronic F127-co-poly(acrylic acid) smart gels were fabricated by using ethylene glycol dimethacrylate (EGDMA) as cross-linker. Free radical polymerization in aqueous medium was initiated by using co-initiators ammonium persulfite (APS) and sodium hydrogen sulfate (SHS). Prepared gels were characterized for pH-sensitivity and in-vitro properties. In addition effect of reactant contents on developed formulation were evaluated by swelling behavior and drug release profile. FTIR spectra revealed the formation of new polymeric network between reactant contents. SEM assay shows rough structure of polymeric matrix which increases the surface area of gel and enhance ability to uptake fluid. TGA and DSC verified that fabricated polymeric smart gels were more thermodynamically stable than pure components. Gel fractions were increased with increase in polymer, monomer and cross-linker contents. Swelling study showed the pH dependent swelling behavior at pH 6.8 of PF127-co-AA polymeric gels. Release pattern of drug followed the first order kinetics, Higuchi and Korsmayer-Peppas models. Toxicity study was also conducted on rabbits and depicted non-toxic effects to biological system. Therefore, PF127-co-AA smart gel can be a potential candidate for the controlled delivery of Ivabradine HCl without any toxic effect.

Keywords

Pluronic F127 Acrylic acid Ivabradine hydrochloride Angina pectoris Controlled release Smart gels 

Notes

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Copyright information

© The Polymer Society, Taipei 2019

Authors and Affiliations

  • Natasha Nasir
    • 1
  • Mahmood Ahmad
    • 1
    • 2
    Email author
  • Muhammad Usman Minhas
    • 3
  • Kashif Barkat
    • 4
  • Muhammad Farooq Khalid
    • 1
  1. 1.Faculty of Pharmacy and Alternative MedicineThe Islamia University of BahawalpurPunjabPakistan
  2. 2.Faculty of PharmacyUniversity of Central PunjabLahorePakistan
  3. 3.College of PharmacyUniversity of SargodhaSargodhaPakistan
  4. 4.Faculty of PharmacyThe University of LahoreLahorePakistan

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