Preparation and characterization of sustained release system based on polyanhydride microspheres with core/shell-like structures

  • I-Ming ChuEmail author
  • Tsang-Hao Liu
  • Yu-Ru Chen


A system for localized drug delivery composed of polyanhydride polymers was studied. The polymers were made via melt-condensation of sebacic acid (SA) with different amount of 1, 3-bis (p-carboxyphenoxy) propane (CPP) as copolymers. By double emulsion technique, microspheres with core/shell-like structure were fabricated. Hydrophilic compound Brilliant Blue G (BBG) was encapsulated in the inner core(s) region with loading efficiencies of 50% ~ 60% for poly (SA) and 40% ~ 45% for poly(SA-CPP) copolymer. Hydrophobic compound, curcumin, was encapsulated in the outer shell region at efficiencies about 90%. Drug release profiles show no initial burst and stable release rates. The studied delivery system was showed to provide stable release for both hydrophilic and hydrophobic compounds simultaneously.


Polyanhydride Microspheres Sustained release Curcumin 



This research is supported by grant 104-2221-E-007-126-MY3 from Ministry of Science and Technology, Taiwan.

Compliance with ethical standards

Conflict of interests

The authors claim no conflict of interests in this study.

Supplementary material

10965_2018_1657_MOESM1_ESM.pdf (156 kb)
ESM 1 (PDF 155 kb)


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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Chemical EngineeringNational Tsing Hua UniversityHsinchuTaiwan

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