Encapsulation of Aspirin into parent and functionalized MCM-41, in vitro release as well as kinetics
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Parent as well as functionalized MCM-41 (by 12-tungstophosphoric acid, TPA) was loaded with poorly soluble drug (Aspirin) and characterized by various physicochemical techniques such as TGA, FT-IR, BET surface area, XRD and TEM. In-vitro controlled release studies of Aspirin, in Simulated Body Fluid (pH 7.4) were carried out under stirring as well as static conditions. Similarly, release study was carried in simulated gastric fluid (pH 1.2), to see the effect of pH on release rate of drug. The influence of 12-tungstophosphoric acid on release rate of drug was also studied. Further, comparison of obtained release profile with marketed formulation (Ecosprin) was carried out. First order release kinetic, Higuchi model, Korsmeyer-Peppas Model and Extended Kinetic Model indicate that the functionalization by inorganic moiety, TPA plays an important role in release of Aspirin.
KeywordsMCM-41 12-Tungstophophoric acid Aspirin Ecosprin Kinetics and Mechanism
PS is thankful to University Grant commission (UGC), New Delhi for the award of Senior Research Fellowship. We are also thankful to Department of Chemistry, The Maharaja Sayajirao University of Baroda, for nitrogen adsorption–desorption analysis.
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Conflict of interest
Author claim no conflict of interest.
- 6.P.M. Ridker, N.R. Cook, I.-M. Lee, D. Gordon, J.M. Gaziano, J.E. Manson, C.H. Hennekens, J.E. Buring, E.N. Engl, J. Med. 352, 1293–1304 (2005)Google Scholar
- 22.F. Andreas, S. Thilo, G.G. Markus, R.P. Greta, Bioorg. Med. Chem. Lett. 1(21), 1162–1166 (2001)Google Scholar
- 32.L. Xia, S. Wang, C. Feng, J. Rare Earths 236, 965–968 (2010)Google Scholar
- 40.S. Pathan, P. Solanki, A. Patel, J. Porous. Mater. 24, 1105–1115 (2017). (Surfactant (CTAB, 4.38 g) and NaOH (1.2 g) were dissolved in 200 mL double distilled water. When the solution became homogeneous, TEOS (20.8 g) was added quickly with stirring. After 5 min, mesitylene (8.64 g) and hexane (3.1 g) was added to the stirred mixture. The resulting thick mixture was stirred vigorously for 10 min and then heated at 85 °C for 2 days with stirring. The resulting product was filtered, washed with double distilled water, dried at 100 °C temperature. The obtained material was calcined at 550 °C in air for 5 h and designated as MCM-41.)Google Scholar
- 43.V. Renganayaki, S. Srinivasan, S. Suriya, Int. J. Chem. Technol. Res. 4(3), 983–990 (2012)Google Scholar
- 44.I.G. Binev, B.A. Stamboliyska, Y.I. Binev, J. Mol. Struct. 378, 189–197 (1996)Google Scholar
- 47.T. Okuhara, N. Mizuno, M. Misono, Adv. Catal. 41, 113–252 (1996)Google Scholar
- 49.G. Singhvi, M. Singh, Int. J. Pharm. Stud. Res. 2(1), 77–84 (2011)Google Scholar
- 50.C. Salome, O. Godswill, O. Ikechukwu, Res. J. Pharm. Biol. Chem. Sci. 4(2), 97–103 (2013)Google Scholar