Transdermal Delivery of Nicotine Using Pectin Isolated from Durian Fruit-Hulls-Based Polymer Blends as a Matrix Layer
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Many natural polymers with various chemical structures are used to prepare transdermal patches. Pectin is a one interesting type of polymer because it can control drug release when used in transdermal patches. In Thailand, the waste from durian fruit-hulls is a major problem for the environment. However, the pectin from it can be isolated under acid conditions and used to prepare transdermal patches for nicotine delivery which has not yet been reported. As the isolated pectin is a natural polymer, the film made from isolated pectin is a brittle; therefore, adding a low protein natural rubber latex (LPNRL) polymer was needed to increase its flexibility. The transdermal patches were amorphous and had Tg values ranging from 81.0 to 93.3 °C. Moisture uptake, swelling ratio, and erosion values of the patches were significantly decreased after addition of LPNRL, which resulted in low hydrophilicity. The in vitro release and permeation of nicotine depends on the hydrophilicity of the patches. The kinetic models for in vitro release and permeation of nicotine were Higuchi model and zero order, respectively. In conclusion, pectin isolated from fruit-hulls of Mon Thong durians is an effective polymer to control the release of nicotine. It also is an option that could solve the environmental problems caused by durian fruit-hulls waste.
KeywordsDurian fruit-hulls Nicotine transdermal patches Pectin Polymer blends
The authors would like to acknowledge the Faculty of Pharmacy and the Research Institute of Rangsit University for their financial support (Grant No. 3/2560). The authors would like to express their gratitude to KI Tull, for her editing and assistance in the English language for this paper.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflicts of interest.
- 15.Hokputsa S, Gerddit W, Pongsamart S, Inngjerdingen K, Heinze T, Koschella A et al (2004) Water-soluble polysaccharides with pharmaceutical importance from Durian rinds (Durio zibethinus Murr.): isolation, fractionation, characterisation and bioactivity. Carbohydr Polym 56:471–481CrossRefGoogle Scholar
- 16.Thairath News (2016) https://www.thairath.co.th/content/967390
- 18.Lipipun V, Nantawanit N, Pongsamart S (2002) Antimicrobial activity (in vitro) of polysaccharide gel from durian fruit-hulls. Songklanakarin J Sci Technol 24:31–38Google Scholar
- 19.Pongsamart S, Nanatawanit N, Lertchaipon J, Lipipun V (eds) (2005) Novel water soluble antibacterial dressing of durian polysaccharide gel. In: Proceeding of III WOCMAP congress on medicinal and aromatic plants, 2005. Thailand, International Society for Horticultural Science (ISHS), Leuven, BelgiumGoogle Scholar
- 20.Pongsamart S, Panmaung T (1998) Isolation of polysaccharides from fruit-hulls of durian (Durio zebethinus L.). Songklanakarin J Sci Technol 20:323–332Google Scholar
- 22.Kohli P, Gupta R (2015) Alkaline pectinases: a review. Biocatal Agric Biotechnol 4:279–285Google Scholar
- 28.Chansiripornchai P, Pramatwinai C, Rungsipipat A, Ponsamart S, Nakchat O (eds) (2005) The efficiency of polysaccharide gel extracted from fruit-hulls of durian (Durio zibethinus L.) for wound healing in pig skin. In: Proceeding of III WOCMAP congress on medicinal and aromatic plants, 2005. Thailand, International Society for Horticultural Science (ISHS), Leuven, BelgiumGoogle Scholar
- 33.Barros NRd, Chagas PAM, Borges FA, Gemeinder JLP, Miranda MCR, Garms BC et al (2015) Diclofenac potassium transdermal patches using natural rubber latex biomembranes as carrier. J Mater 1–7Google Scholar
- 35.Roberts AD (1998) Natural rubber chemistry and technology. Oxford University Press, OxfordGoogle Scholar
- 37.Isralowitz R (2015) Drug use: a reference handbook. ABC-CLIO, Santa BarbaraGoogle Scholar