The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis

  • Vida Vafaizadeh
  • Emilia Peuhu
  • Marja L. Mikkola
  • Walid T. Khaled
  • Mohamed Bentires-Alj
  • Zuzana KoledovaEmail author


The eleventh annual workshop of the European Network for Breast Development and Cancer, Methods in mammary gland biology and breast cancer, took place on the 16th to 18th of May 2019 in Weggis, Switzerland. The main topics of the meeting were high resolution genomics and proteomics for the study of mammary gland development and cancer, breast cancer signaling, tumor microenvironment, preclinical models of breast cancer, and tissue morphogenesis. Exciting novel findings in, or highly relevant to, mammary gland biology and breast cancer field were presented, with insights into the methods used to obtain them. Among others, the discussed methods included single-cell RNA sequencing, genetic barcoding, lineage tracing, spatial transcriptomics, optogenetics, genetic mouse models and organoids.


Barcoding Proteomics Signaling Tissue morphogenesis Transcriptomics Tumor microenvironment 



p53-binding protein 1


BRCA1 DNA repair associated


cyclic adenosine monophosphate


cancer-associated fibroblast


cell division cycle 42 effector protein 3


cAMP responsive element binding protein 1


epithelial growth factor receptor


extracellular matrix


European Molecular Biology Laboratory


European Network of Breast Development and Cancer


estrogen receptor


fibroblast growth factor


fibroblast growth factor receptor


invasive ductal carcinoma


mammary stem/progenitor cell


notch receptor 4


poly (ADP-ribose) polymerase


PARP inhibitor


progesterone receptor


p90 ribosomal S6 kinase 2


single cell RNA sequencing


triple negative breast cancer


United Kingdom


vacuolar protein sorting-associated protein 11 homolog


Yes-associated protein



The authors thank Xiomara Banholzer for help with the organization of the meeting.

Authors’ Contributions

VV, EP, MLM, WTK, MB-A, and ZK wrote the manuscript. All authors approved the final manuscript.

Funding Information

Funding for the meeting was received from Krebsforschung Schweiz and Krebsliga Schweiz, Novartis, The Company of Biologists, Frontiers in Cell and Developmental Biology, Cytoskeleton Inc., and from European Association for Cancer Research. VV has been supported by the Swiss National Science Foundation, EP has been supported by Academy of Finland and Finnish Cultural foundation. MLM received funding from Academy of Finland, Cancer Foundation Finland, and Sigrid Juselius Foundation. Research in the MB-A laboratory is supported by the Swiss Initiative for Systems Biology- SystemsX, the European Research Council (grant no. 694033 STEM-BCPC), the Swiss National Science Foundation, Novartis, the Krebsliga Beider Basel, the Swiss Cancer League, the Swiss Personalized Health Network (Swiss Personalized Oncology driver project) and the Department of Surgery of the University Hospital Basel. ZK is supported by the Grant Agency of Masaryk University (grants no. MUNI/G/1446/2018 and MUNI/E/0519/2019).

Compliance with Ethical Standards

Ethics Approval and Consent to Participate

Not applicable.

Consent for Publication

The manuscript has been read and approved by all authors, has not been published previously in print or electronic format, and is not under consideration by another publication or electronic medium. Consent for publication has been obtained from all the speakers.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of BiomedicineUniversity of BaselBaselSwitzerland
  2. 2.Turku Bioscience CentreUniversity of Turku and Åbo Akademi UniversityTurkuFinland
  3. 3.Cancer Research Laboratory FICAN WestUniversity of Turku and Turku University HospitalTurkuFinland
  4. 4.Developmental Biology Program, Institute of Biotechnology, HiLIFEUniversity of HelsinkiHelsinkiFinland
  5. 5.Department of PharmacologyUniversity of CambridgeCambridgeUK
  6. 6.Department of Biomedicine, Department of SurgeryUniversity Hospital Basel, University of BaselBaselSwitzerland
  7. 7.Department of Histology and Embryology, Faculty of MedicineMasaryk UniversityBrnoCzech Republic

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