The Eleventh ENBDC Workshop: Advances in Technology Help to Unveil Mechanisms of Mammary Gland Development and Cancerogenesis
The eleventh annual workshop of the European Network for Breast Development and Cancer, Methods in mammary gland biology and breast cancer, took place on the 16th to 18th of May 2019 in Weggis, Switzerland. The main topics of the meeting were high resolution genomics and proteomics for the study of mammary gland development and cancer, breast cancer signaling, tumor microenvironment, preclinical models of breast cancer, and tissue morphogenesis. Exciting novel findings in, or highly relevant to, mammary gland biology and breast cancer field were presented, with insights into the methods used to obtain them. Among others, the discussed methods included single-cell RNA sequencing, genetic barcoding, lineage tracing, spatial transcriptomics, optogenetics, genetic mouse models and organoids.
KeywordsBarcoding Proteomics Signaling Tissue morphogenesis Transcriptomics Tumor microenvironment
p53-binding protein 1
BRCA1 DNA repair associated
cyclic adenosine monophosphate
cell division cycle 42 effector protein 3
cAMP responsive element binding protein 1
epithelial growth factor receptor
European Molecular Biology Laboratory
European Network of Breast Development and Cancer
fibroblast growth factor
fibroblast growth factor receptor
invasive ductal carcinoma
mammary stem/progenitor cell
notch receptor 4
poly (ADP-ribose) polymerase
p90 ribosomal S6 kinase 2
single cell RNA sequencing
triple negative breast cancer
vacuolar protein sorting-associated protein 11 homolog
The authors thank Xiomara Banholzer for help with the organization of the meeting.
VV, EP, MLM, WTK, MB-A, and ZK wrote the manuscript. All authors approved the final manuscript.
Funding for the meeting was received from Krebsforschung Schweiz and Krebsliga Schweiz, Novartis, The Company of Biologists, Frontiers in Cell and Developmental Biology, Cytoskeleton Inc., and from European Association for Cancer Research. VV has been supported by the Swiss National Science Foundation, EP has been supported by Academy of Finland and Finnish Cultural foundation. MLM received funding from Academy of Finland, Cancer Foundation Finland, and Sigrid Juselius Foundation. Research in the MB-A laboratory is supported by the Swiss Initiative for Systems Biology- SystemsX, the European Research Council (grant no. 694033 STEM-BCPC), the Swiss National Science Foundation, Novartis, the Krebsliga Beider Basel, the Swiss Cancer League, the Swiss Personalized Health Network (Swiss Personalized Oncology driver project) and the Department of Surgery of the University Hospital Basel. ZK is supported by the Grant Agency of Masaryk University (grants no. MUNI/G/1446/2018 and MUNI/E/0519/2019).
Compliance with Ethical Standards
Ethics Approval and Consent to Participate
Consent for Publication
The manuscript has been read and approved by all authors, has not been published previously in print or electronic format, and is not under consideration by another publication or electronic medium. Consent for publication has been obtained from all the speakers.
Conflict of Interest
The authors declare that they have no conflict of interest.
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