In-Situ Synthesis of a Novel Bioresorbable Sodium Alginate/Hydroxyapatite–Calcium Pyrophosphate Nanocomposite as Bone Replacement

  • Esmaeil SalimiEmail author


The aim of this study was to develop a new bioresorbable nanocomposite for bone defect treatment. Despite different orthopaedic applications of hydroxyapatite (HA), the slow resorption rate and the instability of HA particles have limited its performance in some particular applications. Therefore, a novel hydroxyapatite–calcium pyrophosphate (HA–CPP)/Alginate nanocomposite was synthesized in this study using the chemical precipitation method. X-ray diffraction pattern indicated the presence of HA and CPP crystals in the composite. Transmission electron microscopy images also showed a combination of nano-size particles with different morphologies. Evaluation of the stability of the prepared samples under physiological condition revealed that the resorption rate was raised by increasing the content of calcium pyrophosphate in the composite. The obtained new composite, which contained the metastable CPP phase, could be the prospective biomaterial for bone replacement.


Nanocomposite Calcium pyrophosphate Bioresorbable Bone replacement 



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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Faculty of Chemical and Materials EngineeringShahrood University of TechnologyShahroodIran

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