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Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies

  • Muhammad Safdar
  • Mehmet Ozaslan
  • Rozhgar A. Khailany
  • Sehrish Latif
  • Yasmeen JunejoEmail author
  • Muhammad Saeed
  • Mustafa S. Al-Attar
  • Belan O. Kanabe
Article
  • 14 Downloads

Abstract

The facile one-pot synthesis method was used to synthesize platinum nanoparticles (Doxy-Pt (0) NPs) by reduction method with doxycycline drug as reducing and capping agent. The combined platinum nanoparticles were carefully chosen for catalytic reduction of paracetamol as well as used against antimicrobial and anticancer actions with the well diffusion process and by measuring the zone of inhibition in mm against Gram-positive (S. aureus and S. pyogenes) and Gram-negative (E. coli and S. typhimurium). The Ultraviolet–Visible-absorption spectroscopy technique was used to endorse accumulation of (Doxy-Pt (0) NPs) using the distinctive Plasmon absorption maxima at 264 nm. Another technique of X-ray powder diffraction (XRD) pattern was used to confirm the crystalline nature of the prepared Pt (0) NPs. Transmission electron microscopy (TEM) was used to study the particle size of the prepared Pt (0) NPs with a size range of 10–20 nm. The catalytic study showed that the reduction is ~ 99.9% of paracetamol that was consummate in a small period of reaction time (60 s) by competent doxycycline based platinum nanoparticles. The value of K is calculated (rate constant) value for paracetamol catalytic reduction was achieved 7 × 10−2 by drawing InC versus time (s) and the results showed that the reaction is of the first command kinetics. Furthermore, the reduction in breast cancer cell viability and proliferation via PtNPs was found higher as compare to the normal breast cells (CRL-4010). Therefore, the newly prepared Doxy-Pt (0) NPs had a marvelous catalytic, antibacterial and anticancerous action as a catalyst and drug material. The recent discoveries are similarly extendable for the preservation of the aquatic situation in contradiction of the pollution produced by paracetamol, microbial and cancerous actions via a superficial, highly inexpensive, quick and effectual technique.

Graphic Abstract

Keywords

Platinum nanoparticles Synthesis Characterization Degradation of paracetamol Antimicrobial activity Cytotoxicity 

Abbreviations

Doxy-Pt-NPs

Doxycycline derived platinum nanoparticles

UV–Vis

Ultraviolet–Visible spectroscopy

XRD

X-ray diffraction

TEM

Transmission electron microscopy

S. aureus

Staphylococcus aureus

S. pyogens

Streptococcus pyogenes

E. coli

Escherichia coli

S. typhimurium

Salmonella typhimurium

NSAIDs

Nonsteroidal anti-inflammatory drugs

CFU

Colony-forming unit

Notes

Acknowledgements

Dr. Yasmeen Junejo would like to thank HEC-Pakistan for providing Assistant Professor (IPFP) position and Dr. Ghulam Shabir, Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan for giving us bacterial strains and the necessary facilities.

Author Contributions

YJ, and MS designed and performed the experiments. SL and RAK performed the measurements. YJ and MS analyzed the measurement data. MS finalized the manuscript. All authors read and approved the final manuscript.

Funding

The study was supported by departmental research grant.

Compliance with Ethical Standards

Conflict of interests

The authors declare that they have no competing interests.

References

  1. 1.
    E.R. Cooper, T.C. Siewicki, K. Phillips, Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment. Sci. Total Environ. 398, 26–33 (2008)CrossRefGoogle Scholar
  2. 2.
    Y. Junejo, M. Safdar, M.A. Akhtar et al., Synthesis of tobramycin stabilized silver nanoparticles and its catalytic and antibacterial activity against pathogenic bacteria. J. Inorg. Organomet. Polym. 29, 111 (2019)CrossRefGoogle Scholar
  3. 3.
    F. Méndez-Arriaga, R. Torres-Palma, C. Pétrier, S. Esplugas, J. Gimenez, C. Pulgarin, Ultrasonic treatment of water contaminated with ibuprofen. Water Res. 42, 4243–4248 (2008)CrossRefGoogle Scholar
  4. 4.
    T. Takagi, C. Ramachandran, M. Bermejo, S. Yamashita, L.X. Yu, G.L. Amidon, A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan. Mol. Pharm. 3, 631–643 (2006)CrossRefGoogle Scholar
  5. 5.
    R. Hirsch, T. Ternes, K. Haberer, K.-L. Kratz, Occurrence of antibiotics in the aquatic environment. Sci. Total Environ. 225, 109–118 (1999)CrossRefGoogle Scholar
  6. 6.
    K. Kümmerer, R. Alexy, J. Hüttig, A. Schöll, Standardized tests fail to assess the effects of antibiotics on environmental bacteria. Water Res. 38, 2111–2116 (2004)CrossRefGoogle Scholar
  7. 7.
    A. Nikolaou, S. Meric, D. Fatta, Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal. Bioanal. Chem. 387, 1225–1234 (2007)CrossRefGoogle Scholar
  8. 8.
    X. Li, G. Li, A review: pharmaceutical wastewater treatment technology and research in China. 2015 Asia-Pacific Energy Equipment Engineering Research Conference. (Atlantis Press, 2015)Google Scholar
  9. 9.
    A.R. Shah, H. Tahir, T. Yasmeen, H.M. Kifayatullah, Electro-Fenton oxidation of simulated pharmaceutical waste: optimization using central composite design. Int. J. Environ. Sci. Nat. Res. 3(5), 555623 (2017)Google Scholar
  10. 10.
    A.M. Abdulla, O.I. Haidar, Spectrophotometric determination of cerium in some ore in Kurdistan Region-Iraq. J. Nat. Sci. Res. 5, 24 (2015)Google Scholar
  11. 11.
    M. Deska, B. Kończak, Immobilized fungal laccase as” green catalyst” for the decolourization process–state of the art. Process Biochem. (2019).  https://doi.org/10.1111/eip.12846 CrossRefGoogle Scholar
  12. 12.
    S. Chen, K. Kimura, Synthesis of thiolate-stabilized platinum nanoparticles in protolytic solvents as isolable colloids. J. Phys. Chem. B 105, 5397–5403 (2001)CrossRefGoogle Scholar
  13. 13.
    P.J. Kulesza, M. Chojak, K. Karnicka, K. Miecznikowski, B. Palys, A. Lewera et al., Network films composed of conducting polymer-linked and polyoxometalate-stabilized platinum nanoparticles. Chem. Mater. 16, 4128–4134 (2004)CrossRefGoogle Scholar
  14. 14.
    H. Song, R.M. Rioux, J.D. Hoefelmeyer, R. Komor, K. Niesz, M. Grass et al., Hydrothermal growth of mesoporous SBA-15 silica in the presence of PVP-stabilized Pt nanoparticles: synthesis, characterization, and catalytic properties. J. Am. Chem. Soc. 128, 3027–3037 (2006)CrossRefGoogle Scholar
  15. 15.
    L. Obreja, D. Pricop, N. Foca, V. Melnig, Platinum nanoparticles synthesis by sonoelectrochemical methods. Mater. Plast 47, 42–47 (2010)Google Scholar
  16. 16.
    A. Abedini, A.R. Daud, M.A.A. Hamid, N.K. Othman, E. Saion, A review on radiation-induced nucleation and growth of colloidal metallic nanoparticles. Nanoscale Res. Lett. 8, 474 (2013)CrossRefGoogle Scholar
  17. 17.
    K.S. Siddiqi, A. Husen, Green synthesis, characterization and uses of palladium/platinum nanoparticles. Nanoscale Res. Lett. 11, 482 (2016)CrossRefGoogle Scholar
  18. 18.
    M.S. Akhtar, J. Panwar, Y.-S. Yun, Biogenic synthesis of metallic nanoparticles by plant extracts. ACS Sustain. Chem. Eng. 1, 591–602 (2013)CrossRefGoogle Scholar
  19. 19.
    K. Omri, N. Alonizan, Effects of ZnO/Mn concentration on the micro-structure and optical Properties of ZnO/Mn–TiO2 nano-composite for applications in photo-catalysis. J. Inorg. Organomet. Polym. 29, 203–212 (2019)CrossRefGoogle Scholar
  20. 20.
    R. Cai, Y. Du, D. Yang, G. Jia, B. Zhu, B. Chen et al., Free-standing 2D nanorafts by assembly of 1D nanorods for biomolecule sensing. Nanoscale Nanoscale 2019(11), 12169 (2019)CrossRefGoogle Scholar
  21. 21.
    V.N. Rao, N.L. Reddy, M.M. Kumari, P. Ravi, M. Sathish, K.M. Kuruvilla, V. Preethi, K.R. Reddy, N.P. Shetti, T.M. Aminabhavi, M.V. Shankar, Photocatalytic recovery of H2 from H2S containing wastewater: surface and interface control of photo-excitons in Cu2S@TiO2 core-shell nanostructures. Appl. Catal. B 254, 174–185 (2019)CrossRefGoogle Scholar
  22. 22.
    C. Venkata Reddy, I. Neelakanta Reddy, B. Akkinepally, K. Raghava Reddy, J. Shim, Synthesis and photoelectrochemical water oxidation of (Y, Cu) codoped α-Fe2O3 nanostructure photoanode. J. Alloys Compd. 814, 152349 (2020)CrossRefGoogle Scholar
  23. 23.
    Y. Junejo, A. Baykal, Ultrarapid catalytic reduction of some dyes by reusable novel erythromycin-derived silver nanoparticles. Turk. J. Chem. 38, 765–774 (2014)CrossRefGoogle Scholar
  24. 24.
    M. Safdar, Y. Junejo, A. Balouch, Efficient degradation of organic dyes by heterogeneous cefdinir derived silver nanocatalyst. J. Ind. Eng. Chem. 31, 216–222 (2015)CrossRefGoogle Scholar
  25. 25.
    K.C. Nguyen, V.L. Seligy, A.F. Tayabali, Cadmium telluride quantum dot nanoparticle cytotoxicity and effects on model immune responses to Pseudomonas aeruginosa. Nanotoxicology 7, 202–211 (2013)CrossRefGoogle Scholar
  26. 26.
    D.V. Ca, L. Sun, J.A. Cox, Optimization of the dispersion of gold and platinum nanoparticles on indium tin oxide for the electrocatalytic oxidation of cysteine and arsenite. Electrochim. Acta 51, 2188–2194 (2006)CrossRefGoogle Scholar
  27. 27.
    I. GyoáKoo, M. SeokáLee, J. HeeáShim, J. HwanáAhn, W. MooáLee, Platinum nanoparticles prepared by a plasma-chemical reduction method. J. Mater. Chem. 15, 4125–4128 (2005)CrossRefGoogle Scholar
  28. 28.
    Y. Junejo, S. Sirajuddin, A. Baykal, M. Safdar, A. Balouch, A novel green synthesis and characterization of Ag NPs with its ultra-rapid catalytic reduction of methyl green dye. Appl. Surf. Sci. 290, 499–503 (2014)CrossRefGoogle Scholar
  29. 29.
    B. Bachiller-Baeza, A. Guerrero-Ruiz, I. Rodríguez-Ramos, Ruthenium-supported catalysts for the stereoselective hydrogenation of paracetamol to 4-trans-acetamidocyclohexanol: effect of support, metal precursor, and solvent. J. Catal. 229, 439–445 (2005)CrossRefGoogle Scholar
  30. 30.
    O. Nasr, O. Mohamed, A.-S. Al-Shirbini, A.-M. Abdel-Wahab, Photocatalytic degradation of acetaminophen over Ag, Au and Pt loaded TiO2 using solar light. J. Photochem. Photobiol. A 374, 185–193 (2019)CrossRefGoogle Scholar
  31. 31.
    S. Khezrianjoo, H. Revanasiddappa, Langmuir-Hinshelwood kinetic expression for the photocatalytic degradation of Metanil Yellow aqueous solutions by ZnO catalyst. Chem. Sci. J. (2012)Google Scholar
  32. 32.
    S. Gurunathan, J.W. Han, D.-N. Kwon, J.-H. Kim, Enhanced antibacterial and anti-biofilm activities of silver nanoparticles against Gram-negative and Gram-positive bacteria. Nanoscale Res. Lett. 9, 373 (2014)CrossRefGoogle Scholar
  33. 33.
    A.F. Halbus, T.S. Horozov, V.N. Paunov, Controlling the antimicrobial action of surface modified magnesium hydroxide nanoparticles. Biomimetics 4, 41 (2019)CrossRefGoogle Scholar
  34. 34.
    A. Misra, S. Jain, D. Kishore, V. Dave, K.R. Reddy, V. Sadhu, J. Dwivedi, S. Sharma, A facile one pot synthesis of novel pyrimidine derivatives of 1, 5-benzodiazepines via domino reaction and their antibacterial evaluation. J. Microbiol. Methods 163, 105648 (2019)CrossRefGoogle Scholar
  35. 35.
    J. Sathiyamoorthy, N. Sudhakar, In vitro cytotoxicity and apoptotic assay in HT-29 cell line using Ficus hispida Linn: Leaves extract. Pharmacogn Mag. 13:S756 (2018).  https://doi.org/10.4103/pm.pm_319_17 CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    J.C. Mohan, G. Praveen, K. Chennazhi, R. Jayakumar, S. Nair, Functionalised gold nanoparticles for selective induction of in vitro apoptosis among human cancer cell lines. J. Exp. Nanosci. 8, 32–45 (2013)CrossRefGoogle Scholar
  37. 37.
    A. Chompoosor, K. Saha, P.S. Ghosh, D.J. Macarthy, O.R. Miranda, Z.J. Zhu et al., The role of surface functionality on acute cytotoxicity, ROS generation and DNA damage by cationic gold nanoparticles. Small 6, 2246–2249 (2010)CrossRefGoogle Scholar
  38. 38.
    S.Y. Choi, S. Jeong, S.H. Jang, J. Park, J.H. Park, K.S. Ock et al., In vitro toxicity of serum protein-adsorbed citrate-reduced gold nanoparticles in human lung adenocarcinoma cells. Toxicol. In Vitro 26, 229–237 (2012)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Muhammad Safdar
    • 1
    • 2
  • Mehmet Ozaslan
    • 2
  • Rozhgar A. Khailany
    • 3
    • 4
  • Sehrish Latif
    • 5
  • Yasmeen Junejo
    • 6
    Email author
  • Muhammad Saeed
    • 7
  • Mustafa S. Al-Attar
    • 8
  • Belan O. Kanabe
    • 2
  1. 1.Department of Breeding and Genetics, Faculty of Animal Production & TechnologyCholistan University of Veterinary & Animal SciencesBahawalpurPakistan
  2. 2.Department of Biology, Division of Molecular Biology and GeneticsGaziantep UniversityGaziantepTurkey
  3. 3.Department of Biology, College of ScienceSalahaddin University-ErbilErbilIraq
  4. 4.Department of Biology, Faculty of EducationTishk International UniversityErbilIraq
  5. 5.Department of BiotechnologyVirtual University of PakistanLahorePakistan
  6. 6.Department of Physiology and Biochemistry, Faculty of Bio-SciencesCholistan University of Veterinary & Animal SciencesBahawalpurPakistan
  7. 7.Department of Poultry Science, Faculty of Animal Production & TechnologyCholistan University of Veterinary & Animal SciencesBahawalpurPakistan
  8. 8.Department of Environmental Science, College of ScienceSalahaddin University-ErbilErbilIraq

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