Synthesis, Characterization and Applications of a Novel Platinum-Based Nanoparticles: Catalytic, Antibacterial and Cytotoxic Studies
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The facile one-pot synthesis method was used to synthesize platinum nanoparticles (Doxy-Pt (0) NPs) by reduction method with doxycycline drug as reducing and capping agent. The combined platinum nanoparticles were carefully chosen for catalytic reduction of paracetamol as well as used against antimicrobial and anticancer actions with the well diffusion process and by measuring the zone of inhibition in mm against Gram-positive (S. aureus and S. pyogenes) and Gram-negative (E. coli and S. typhimurium). The Ultraviolet–Visible-absorption spectroscopy technique was used to endorse accumulation of (Doxy-Pt (0) NPs) using the distinctive Plasmon absorption maxima at 264 nm. Another technique of X-ray powder diffraction (XRD) pattern was used to confirm the crystalline nature of the prepared Pt (0) NPs. Transmission electron microscopy (TEM) was used to study the particle size of the prepared Pt (0) NPs with a size range of 10–20 nm. The catalytic study showed that the reduction is ~ 99.9% of paracetamol that was consummate in a small period of reaction time (60 s) by competent doxycycline based platinum nanoparticles. The value of K is calculated (rate constant) value for paracetamol catalytic reduction was achieved 7 × 10−2 by drawing InC versus time (s) and the results showed that the reaction is of the first command kinetics. Furthermore, the reduction in breast cancer cell viability and proliferation via PtNPs was found higher as compare to the normal breast cells (CRL-4010). Therefore, the newly prepared Doxy-Pt (0) NPs had a marvelous catalytic, antibacterial and anticancerous action as a catalyst and drug material. The recent discoveries are similarly extendable for the preservation of the aquatic situation in contradiction of the pollution produced by paracetamol, microbial and cancerous actions via a superficial, highly inexpensive, quick and effectual technique.
KeywordsPlatinum nanoparticles Synthesis Characterization Degradation of paracetamol Antimicrobial activity Cytotoxicity
Doxycycline derived platinum nanoparticles
Transmission electron microscopy
- S. aureus
- S. pyogens
- E. coli
- S. typhimurium
Nonsteroidal anti-inflammatory drugs
Dr. Yasmeen Junejo would like to thank HEC-Pakistan for providing Assistant Professor (IPFP) position and Dr. Ghulam Shabir, Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan for giving us bacterial strains and the necessary facilities.
YJ, and MS designed and performed the experiments. SL and RAK performed the measurements. YJ and MS analyzed the measurement data. MS finalized the manuscript. All authors read and approved the final manuscript.
The study was supported by departmental research grant.
Compliance with Ethical Standards
Conflict of interests
The authors declare that they have no competing interests.
- 8.X. Li, G. Li, A review: pharmaceutical wastewater treatment technology and research in China. 2015 Asia-Pacific Energy Equipment Engineering Research Conference. (Atlantis Press, 2015)Google Scholar
- 9.A.R. Shah, H. Tahir, T. Yasmeen, H.M. Kifayatullah, Electro-Fenton oxidation of simulated pharmaceutical waste: optimization using central composite design. Int. J. Environ. Sci. Nat. Res. 3(5), 555623 (2017)Google Scholar
- 10.A.M. Abdulla, O.I. Haidar, Spectrophotometric determination of cerium in some ore in Kurdistan Region-Iraq. J. Nat. Sci. Res. 5, 24 (2015)Google Scholar
- 15.L. Obreja, D. Pricop, N. Foca, V. Melnig, Platinum nanoparticles synthesis by sonoelectrochemical methods. Mater. Plast 47, 42–47 (2010)Google Scholar
- 21.V.N. Rao, N.L. Reddy, M.M. Kumari, P. Ravi, M. Sathish, K.M. Kuruvilla, V. Preethi, K.R. Reddy, N.P. Shetti, T.M. Aminabhavi, M.V. Shankar, Photocatalytic recovery of H2 from H2S containing wastewater: surface and interface control of photo-excitons in Cu2S@TiO2 core-shell nanostructures. Appl. Catal. B 254, 174–185 (2019)CrossRefGoogle Scholar
- 31.S. Khezrianjoo, H. Revanasiddappa, Langmuir-Hinshelwood kinetic expression for the photocatalytic degradation of Metanil Yellow aqueous solutions by ZnO catalyst. Chem. Sci. J. (2012)Google Scholar