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A New Cu(II)-Containing Coordination Polymer: Crystal Structure, Molecular Docking and Protective Effect on Primary Focal Segmental Glomerulosclerosis by Regulating NF-κB Pathway

  • He-Ping Zhang
  • Dan Xu
  • Jie Zhang
  • Jia-Li Liu
  • Kun Yang
  • Yan-Lin Yue
  • Yan-Ni Zhang
  • Liang-Hong YiEmail author
Article
  • 16 Downloads

Abstract

A new type of glycine bridged Cu(II)-containing Schiff base coordination polymer {[Cu2(HL)2](H2O)4}n (1, H3L = (2,2′-(((1E,1′E)-(2-hydroxy-5-methyl-1,3-phenylene)bis(methaneylylidene))bis(azaneylylidene))diacetic acid) was composed by the condensation of glycine, Cu(NO3)2·6H2O as well as 2,6-diformyl-4-methylphenol in the water surrounding. To make the size of complex 1 in nanoscale, a green grinding treatment approach was utilized to generate the nano sheets of complex 1 which has excellent water dispersibility. We firstly constructed the primary focal segmental glomerulosclerosis mice model and evaluate the reduction effect of nano 1 on the level of 24-h urine protein contents. Then, the nf-κb and tlr4 gene expression level was measured by RT-PCR to reveal the mechanism of nano 1. Further, motivated by the drug-like potential that observed from experimental results, the binding interaction has been probed by using molecular docking simulation.

Keywords

Coordination polymer Schiff base ligand Cu(II)-complex Glomerulosclerosis Molecular docking 

Notes

Supplementary material

10904_2019_1353_MOESM1_ESM.docx (77 kb)
Supplementary material 1 (DOCX 74 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • He-Ping Zhang
    • 1
    • 2
  • Dan Xu
    • 1
    • 2
  • Jie Zhang
    • 2
  • Jia-Li Liu
    • 2
  • Kun Yang
    • 2
  • Yan-Lin Yue
    • 2
  • Yan-Ni Zhang
    • 2
  • Liang-Hong Yi
    • 1
    Email author
  1. 1.Department of UrologyThe First Affiliated Hospital of Jinan UniversityGuangzhouChina
  2. 2.Department of UrologyAffiliated Hospital of North Sichuan Medical CollegeNanchongChina

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