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Highly Augmented Antioxidant and Anticancer Effect of Biocompatible MIL-100(Fe)@SiO2-Immobilized Green Tea Catechin

  • Xiang Ke
  • Nianqiao Qin
  • Tian Zhang
  • Fei KeEmail author
  • Xiqing YanEmail author
Article
  • 8 Downloads

Abstract

Green tea catechins have attracted much attention in the areas of biomedicine due to their natural antioxidant activity and numerous beneficial therapeutic effects. However, the chemically unstable in neutral and alkaline aqueous solutions have hindered their development. In this work, a nanosized non-toxic porous Fe-based metal–organic frameworks (MOFs) nanocomposites with a MIL-100(Fe) core and a silica shell was fabricated and applied for the loading of a typical green tea catechin, gallic acid (GA). The amount of GA loaded in the sample is shown to be 0.23 g g−1, and it took as long as 85 h to complete the GA release in PBS at 37 °C. Furthermore, the antioxidant activity results show that MIL-100(Fe)@SiO2-GA can highly enhance the antioxidant activity in PBS solution. Moreover, the obtained biocompatible MIL-100(Fe)@SiO2-GA displayed highly augmented anticancer effect on C6 cells. This work demonstrates that the prepared MIL-100(Fe)@SiO2 nanoparticles are potential green tea catechins carriers in terms of their good biocompatibility and effective performance in the antioxidant and anticancer activity.

Keywords

Metal–organic frameworks Biocompatibility Gallic acid Antioxidant activity Tumour therapy 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (NSFC, 21501003), Natural Science Foundation of Anhui Province (Grant No. 1608085QB27), the Key Research Projects of University in Henan province (Grant No. 15A350012), and China Postdoctoral Science Foundation funded project (Grant No. 2015M581973).

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.College of PharmacyXinxiang Medical UniversityXinxiangPeople’s Republic of China
  2. 2.Department of PharmacyThe First Affiliated Hospital of University of Science and Technology of China and Anhui Provincial Cancer HospitalHefeiPeople’s Republic of China
  3. 3.Department of Applied ChemistryAnhui Agricultural UniversityHefeiPeople’s Republic of China

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