Synthesis of Large-Pore Silica Microspheres Using Dodecylamine as a Catalyst, Template and Porogen Agent

  • Lingping Cheng
  • Jianfeng Cai
  • Yanxiong KeEmail author


This paper reports a strategy combing a modified Stöber method and a post-hydrothermal treatment for the fabricating of silica microspheres with large pores. Dodecylamine (DDA), used as a catalyst, template and porogen agent, plays an important role in controlling both the particle morphology and the pore expansion. By adjusting the concentration of DDA (20, 40 and 80 mmol/L) and the temperature of hydrothermal treatment (80–140 °C), the pore size ranging from 3.5 to 16 nm could be obtained. The synthesized sub-2 µm silica spheres were modified with dimethyloctadecylchlorosilane (C18) and successfully applied for the separation of aromatic compounds in high-performance liquid chromatography (HPLC). The silica may be a good candidate as HPLC packing materials.


Dodecylamine Sol–gel process Mesoporous silica spheres HPLC 



This work was supported by the National Natural Science Foundation of China (Grant No. 21375038).


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of EducationEast China University of Science and TechnologyShanghaiPeople’s Republic of China

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