Synthesis, Structure and In Vitro Anti-gastric Cancer Activity of Two New Mixed-Ligand Cu(II) and Cd(II)-Coordination Polymers

  • Xiao-Long WanEmail author
  • Lei Dong
  • Jia-Zhong Wang
  • Hai-Tao Shi
  • Long-Bao Yang


By using a strategy of introducing two organic ligands with different donor groups, two new Cu(II) and Cd(II) coordination polymers (CPs) [Cu3(OH)(pz)3(Hpz)(H2O)(ipa)](H2O)4 (1, Hpz = pyrazol, H2ipa = isophthalic acid) and [Cd(phen)(ndc)](H2O) (2, phen = 1,10-phenanthroline, H2ndc = 1,2-naphthalene dicarboxylic acid) are synthesized and characterized. The molecular structures of the as-prepared CPs were determined by the single crystal X-ray diffraction (SCXRD) studies and their phase purities have been confirmed via the power X-day diffraction analysis (PXRD). The Cu(II)-based complex 1 is composed of trinuclear Cu33-OH)(pz)3 clusters that extended by the ipa2− ligands into a 1D left-handed helical chain along the c axis. In complex 2, the ndc2− ligands connect with the binuclear Cd2 unit along the c axis to shape a 1D chain-like structure, which is further stacked into a 2D layered network via π–π stacking. The as-prepared two CPs transformed to the nanoscale regime by mechanical grinding to yield nano 1 and nano 2 with excellent water dispersibility, maintaining its crystallinity. In addition, the in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were conducted on the gastric cancer cell line AGS with increasing concentrations of the two nanosized CPs, which reveal their promising anticancer activity.


Coordination polymers Mixed-linker Mechanical grinding MTT assay 



  1. 1.
    J. Reedijk, Eur. J. Inorg. Chem. 2009, 1303–1312 (2009)CrossRefGoogle Scholar
  2. 2.
    W.I. Sundquist, S.J. Lippard, Coord. Chem. Rev. 100, 293–322 (1990)CrossRefGoogle Scholar
  3. 3.
    E.R. Jamieson, S.J. Lippard, Chem. Rev. 99, 2467–2498 (1999)CrossRefGoogle Scholar
  4. 4.
    S. Richardson, Int. J. Pharm. 178, 231–243 (1999)CrossRefGoogle Scholar
  5. 5.
    J.Y. Lu, Coord. Chem. Rev. 246, 327–347 (2003)CrossRefGoogle Scholar
  6. 6.
    C.W. Duan, L.X. Hu, J.L. Ma, J. Mater. Chem. A 6, 6309–6318 (2018)CrossRefGoogle Scholar
  7. 7.
    Y. Feng, H. Fan, Z. Zhong, H. Wang, D. Qiu, Inorg. Chem. 55, 11987–11992 (2016)CrossRefGoogle Scholar
  8. 8.
    Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, H. Shi, Dalton Trans. 44, 894–897 (2015)CrossRefGoogle Scholar
  9. 9.
    S. Mukherjee, S. Ganguly, K. Manna, S. Mondal, S. Mahapatra, D. Das, Inorg. Chem. 57, 4050–4060 (2018)CrossRefGoogle Scholar
  10. 10.
    B.M. Zeglis, V. Divilov, J.S. Lewis, J. Med. Chem. 54, 2391–2398 (2011)CrossRefGoogle Scholar
  11. 11.
    Y.H. Liu, A. Li, J. Shao, C.Z. Xie, X.Q. Song, W.G. Bao, J.Y. Xu, Dalton Trans. 45, 8036–8049 (2016)CrossRefGoogle Scholar
  12. 12.
    S.S. Bhat, A.A. Kumbhar, H. Heptullah, A.A. Khan, V.V. Gobre, S.P. Gejji, V.G. Puranik, Inorg. Chem. 50, 545–558 (2011)CrossRefGoogle Scholar
  13. 13.
    T. Karmakar, Y. Kuang, N. Neamati, J.B. Baruah, Polyhedron 54, 285–293 (2013)CrossRefGoogle Scholar
  14. 14.
    N. Zhang, Y. Fan, Z. Zhang, J. Zuo, P. Zhang, Q. Wang, S. Liu, C. Bi, Inorg. Chem. Commun. 22, 68–72 (2012)CrossRefGoogle Scholar
  15. 15.
    B. Afzalian Mend, M. Delavar, M. Darroudi, J. Mol. Struct. 1134, 599–605 (2017)CrossRefGoogle Scholar
  16. 16.
    G.M. Sheldrick, Acta Crystallogr. Sect. C 71, 3–8 (2015)CrossRefGoogle Scholar
  17. 17.
    D. Chen, W. Shi, P. Cheng, Chem. Commun. 51, 370–372 (2015)CrossRefGoogle Scholar
  18. 18.
    J.F. Ma, J. Yang, G.L. Zheng, J.F. Li, Liu, Inorg. Chem. 42, 7531–7534 (2003)CrossRefGoogle Scholar
  19. 19.
    A.L. Spek, Acta Crystallogr. Sect. C 71, 9–18 (2015)CrossRefGoogle Scholar
  20. 20.
    D. Sun, L.L. Han, S. Yuan, Y.K. Deng, M.Z. Xu, D.F. Sun, Cryst. Growth Des. 13, 377–385 (2013)CrossRefGoogle Scholar
  21. 21.
    G. Liu, Y. Chen, X. Wang, B. Chen, H. Lin, J. Solid State Chem. 182, 566–573 (2009)CrossRefGoogle Scholar
  22. 22.
    T. Kundu, S. Mitra, P. Patra, A. Goswami, D. Díaz Díaz, R. Banerjee, Chemistry 20, 10514–10518 (2014)CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Xiao-Long Wan
    • 1
    Email author
  • Lei Dong
    • 1
  • Jia-Zhong Wang
    • 2
  • Hai-Tao Shi
    • 1
  • Long-Bao Yang
    • 1
  1. 1.Department of GastroenterologySecond Affiliated Hospital of Xi’an Jiaotong UniversityXi’anPeople’s Republic of China
  2. 2.General SurgerySecond Affiliated Hospital of Xi’an Jiaotong UniversityXi’anPeople’s Republic of China

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