Advertisement

A pH-Responsive Molecularly Imprinted Hydrogel for Dexamethasone Release

  • Pengju Wei
  • Runmin Song
  • Cheng Chen
  • Zhanhong Li
  • Zhigang Zhu
  • Songjun Li
Article
  • 5 Downloads

Abstract

A new type of pH-responsive molecularly imprinted polymer (MIP) hydrogel was reported, which can well control the release of dexamethasone sodium phosphate (DXP). The MIP hydrogel were prepared by precipitation polymerization using dopamine acrylamide (DPA) and acrylic acid (AAc) as functional monomers and DXP as the template molecule. The synthesized MIP hydrogel were characterized by SEM and FT-IR spectrometer. The rates of drug loading and drug release were determined by UV spectroscopy analysis. The results showed that the drug loading rate of MIP hydrogel was significantly higher than that of NIP hydrogel when immersed in different DXP solutions. Only 58% of the loaded drug released from MIP hydrogel in 24 h while the released drug exceed 80% for the NIP hydrogel, and such controlled slow release characteristics of MIP hydrogel sustained 7 days. Furthermore, the DXP-imprinted hydrogel exhibited pH-dependent due to the molecular interaction between the polymerized DPA and AAc.

Graphical Abstract

Keywords

Molecularly imprinted Hydrogel pH-responsive Controlled release 

Notes

Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 61471233, 21504051), the Program for Professor of Special Appointment (Eastern Scholar) at SIHL, Gaoyuan Discipline of Shanghai-Environmental Science and Engineering (Resource Recycling Science and Engineering) and the Graduate Program Foundation of Shanghai Polytechnic University (EGD17YJ0042).

References

  1. 1.
    A. Pantelopoulos, N.G. Bourbakis, IEEE Trans. Syst. Man Cybern. C. 40, 1 (2010)CrossRefGoogle Scholar
  2. 2.
    Z.G. Zhu, L. Garcia-Gancedo, A.J. Flewitt, H.Q. Xie, F. Moussy, W.I. Milne, Sensors. 12, 5996 (2012)CrossRefPubMedGoogle Scholar
  3. 3.
    S. Pan, Z.H. Li, Y. Chen, X.L. Zhao, C. Chen, Z.G. Zhu, Chem. J. Chin. Univ. 38, 1163 (2017) (In Chinese)Google Scholar
  4. 4.
    S.P. Nichols, A. Koh, W.L. Storm, J.H. Shin, M.H. Schoenfisch, Chem. Rev. 113, 2528 (2013)CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    N. Wisniewski, F. Moussy, W.M. Reichert, Fresenius J. Anal. Chem. 366, 611 (2000)CrossRefPubMedGoogle Scholar
  6. 6.
    J. Li, X.D. Wang, APL Mater. 5, 073801 (2017)CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    J.M. Morais, F. Papadimitrakopoulos, D.J. Burgess, AAPS J. 12, 188 (2010)CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    K.Y. Lee, D.J. Mooney, Chem. Rev. 101, 1869 (2001)CrossRefPubMedGoogle Scholar
  9. 9.
    C.Y. Wang, B.Z. Yu, B. Knudsen, J. Harmon, F. Moussy, Y. Moussy, Biomacromolecules. 9, 561 (2008)CrossRefPubMedGoogle Scholar
  10. 10.
    J.Y. Yu, Z.H. Li, C. Chen, Y.X. Wang, Z.G. Zhu, J. Biomed. Eng. 33, 991 (2016) (In Chinese)Google Scholar
  11. 11.
    Y.M. Ju, B.Z. Yu, L. West, Y. Moussy, F. Moussy, J. Biomed. Mater. Res. Part A. 92A, 650 (2010)Google Scholar
  12. 12.
    L.W. Norton, H.E. Koschwanez, N.A. Wisniswski, B. Klizman, W.M. Reichert, J. Biomed. Mater. Res. Part A. 81A, 858 (2007)CrossRefGoogle Scholar
  13. 13.
    C. Chen, X.L. Zhao, Z.H. Li, Z.G. Zhu, S.H. Qian, A.J. Flewitt, Sensors. 17, 182 (2017)CrossRefGoogle Scholar
  14. 14.
    S.D. Patil, F. Papadmitrakopoulos, D.J. Burgess, J. Control. Release. 117, 68 (2007)CrossRefPubMedGoogle Scholar
  15. 15.
    T.R. Hoare, D.S. Kohane, Polymer. 49, 1993 (2008)CrossRefGoogle Scholar
  16. 16.
    J. Ashley, M.A. Shahbazi, K. Kant, V.A. Chidambara, A. Wolff, D.D. Bang, Y. Sun, Biosens. Bioelectron. 91, 606 (2017)CrossRefPubMedGoogle Scholar
  17. 17.
    A. Cunliffe, A. Kirby, C. Alexander, Adv. Drug Deliv. Rev. 57, 1836 (2005)PubMedGoogle Scholar
  18. 18.
    L.X. Chen, X.Y. Wang, W.H. Lu, X.Q. Wu, J.H. Li, Chem. Soc. Rev. 45, 2137 (2016)CrossRefPubMedGoogle Scholar
  19. 19.
    M.E. Manesh, M. Javanbakht, F. Atyabi, A. Mohammadi, S. Mohammadi, B.A. Adergani, R. Dinarvand, Mat. Sci. Eng. C. 31, 1692 (2011)CrossRefGoogle Scholar
  20. 20.
    M. Abdouss, E. Asadi, S.A. Deilami, N. Beik-mohammadi, S.A. Aslanzadeh, J. Mater. Sci. 22, 2273 (2011)Google Scholar
  21. 21.
    H. Hiratani, A. Fujiwara, Y. Tamiya, Y. Mizutani, C.A. Lorenzob, Biomaterials. 26, 1293 (2005)CrossRefPubMedGoogle Scholar
  22. 22.
    B.M. Nikouei, F.A. Ghaeni, V.S. Motamedshariaty, S.A. Mohajeri, J. Appl. Polym. Sci. 126, 387 (2012)CrossRefGoogle Scholar
  23. 23.
    X.F. Lu, Y.F. Shi, H.L. Lv, Y.Y. Fu, D. Ma, W.J. Xue, Mater. Sci. 25, 1461 (2014)Google Scholar
  24. 24.
    G. Cirillo, M. Curcio, O.I. Parisi, F. Puoci, F. Iemma, U.G. Spizzirri, D. Restuccia, N. Picci, Food Chem. 125, 1058 (2011)CrossRefGoogle Scholar
  25. 25.
    M. Javanbakht, A.M. Attaran, M.H. Namjumanesh, M.E. Manesh, B. Akbari-adergani, J. Chromatogr. B 878, 1700 (2010)CrossRefGoogle Scholar
  26. 26.
    A. Asadi, S.A. Deilami, M. Abdouss, D. Kordestani, A. Rahimi, S. Asadi, Korean J. Chem. Eng. 31, 1028 (2014)CrossRefGoogle Scholar
  27. 27.
    A. Mohebali, M. Abdouss, S. Mazinani, P. Zahedi, Polym. Adv.Technol. 27, 1164 (2016)CrossRefGoogle Scholar
  28. 28.
    Y.Q. Lv, T.W. Tan, F. Sve, Biotechnol. Adv. 31, 1172 (2013)CrossRefPubMedGoogle Scholar
  29. 29.
    L. Han, X. Lu, K.Z. Liu, K.F. Wang, L.M. Fang, L.T. Weng, H.P. Zhang, Y.H. Tang, F.Z. Ren, C.C. Zhao, G.X. Sun, R. Liang, Z.J. Li, J. ACS Nano. 11, 2561 (2017)CrossRefGoogle Scholar
  30. 30.
    S.J. Li, A. Tiwari, Y. Ge, D. Fei, Adv. Mat. Lett. 1, 4 (2010)CrossRefGoogle Scholar
  31. 31.
    M. Vermeulen, M. Giordano, A.S. Trevani, C. Sedlik, R. Gamberale, P.F. Calotti, G. Salamone, S. Raiden, J. Sanjurjo, J.R. Geffner, J. Immunol. 172, 3196 (2004)CrossRefPubMedGoogle Scholar
  32. 32.
    J. Kim, A. Chauhan, Int. J. Pharm. 353, 205 (2008)PubMedGoogle Scholar
  33. 33.
    W.J. Wei, M.Y. Zhu, X.J. Shen, S.P. Wu, S.J. Li, RSC Adv. 6, 42869 (2016)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Environmental and Materials EngineeringShanghai Polytechnic UniversityShanghaiChina
  2. 2.Research Center of Resource Recycling Science and EngineeringShanghai Polytechnic UniversityShanghaiChina
  3. 3.School of Materials Science and EngineeringJiangsu UniversityZhenjiangChina

Personalised recommendations