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Preparation of Biodegradable Polymer Nanospheres Containing Manganese Porphyrin (Mn-Porphyrin)

  • Fuminori Ito
  • Hidetaka Yamada
  • Kiyoshi Kanamura
  • Hiroyoshi Kawakami
Article

Abstract

Herein, poly(lactide-co-glycolide) (PLGA) nanospheres containing Mn-porphyrin, which exhibit chemically versatile and promising superoxide dismutase mimic, were prepared for biomaterial and drug-delivery-system formulations. The particle sizes and Mn-porphyrin-loading efficiencies of the nanospheres were controlled in order to realize breakthrough therapies for the incurable diseases. The sizes of the prepared Mn-porphyrin/PLGA nanospheres increased with the amount of PLGA used during preparation. Furthermore, the w1-to-o-phase volume ratio affected the loading efficiency of the Mn-porphyrin into the nanospheres. Nanospheres prepared from PLGA of lower molecular weight exhibited higher Mn-porphyrin-loading efficiencies. Furthermore, nanospheres prepared from PLGA with a molecular weight of 5000 exhibited a loading efficiency of 60%, which is higher than those generally reported for other nanospheres (~ 10%). Release testing revealed that the molecular weight of the PLGA influenced the release behaviour of the Mn-porphyrin from the nanospheres. Hence, Mn-porphyrin/PLGA nanospheres with controllable particle sizes, loading efficiencies, and release behaviour were prepared.

Keywords

PLGA nanospheres Mn-porphyrin Emulsion Particle size Loading efficiency 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Applied Chemistry, Graduate School of Urban Environmental SciencesTokyo Metropolitan UniversityTokyoJapan
  2. 2.Chemical Research GroupResearch Institute of Innovative Technology for the Earth (RITE)KyotoJapan

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