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Journal of Immigrant and Minority Health

, Volume 21, Issue 3, pp 549–554 | Cite as

Direct-Acting Antiviral Therapy for Hepatitis C Infection in a Large Immigrant Community

  • Amber R. TierneyEmail author
  • William Huepfel
  • Aasma P. Shaukat
  • John R. Lake
  • Mark Boldt
  • Qi Wang
  • Mohamed A. Hassan
Original Paper
  • 71 Downloads

Abstract

Hepatitis C treatment has rapidly evolved with the arrival of direct-acting antiviral therapy. Sustained virologic response (SVR) rates in clinical trials are high but it is unknown how this translates to the immigrant community. Data from December 2013 to September 2015 was collected from a Midwest academic and community practice with a large immigrant population. There were 802 patients with an overall SVR rate of 88%. Ledipasvir/sofosbuvir was associated with favorable response among genotype 1 and 4 patients compared to other regimens (p < 0.001 and p = 0.05). Factors associated with treatment failure included advanced liver disease, male gender, East African/Middle Eastern ethnicity, and non-compliance. Patients with genotype 4 had lower SVR rates than other genotypes (58% vs. 89%, p < 0.001), particularly among East Africans (40% vs. 82% for other ethnicities). Our SVR rate for genotype 4 infection is lower than clinical trials and may be related to cultural, biologic and socioeconomic factors.

Keywords

Hepatitis C Antiviral Cirrhosis Ethnicity 

Notes

Funding

No funding was needed to complete this study.

Compliance with Ethical Standards

Conflict of interest

John Lake has received research grants from AbbVie and Mark Boldt has an advisory arrangement for Gilead and AbbVie and is a consultant with AbbVie. All remaining authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was waived from individual participants based on exempt status as a retrospective chart review. This study was reviewed and approved by the Institutional Review Board at the University of Minnesota.

Research Involving Human and Animal Rights

This article does not contain any studies with animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Amber R. Tierney
    • 1
    Email author
  • William Huepfel
    • 1
  • Aasma P. Shaukat
    • 2
  • John R. Lake
    • 1
  • Mark Boldt
    • 3
  • Qi Wang
    • 1
  • Mohamed A. Hassan
    • 1
  1. 1.Department of Internal Medicine, Division of Gastroenterology, Hepatology and NutritionUniversity of MinnesotaMinneapolisUSA
  2. 2.Division of GastroenterologyMinneapolis Veterans Affairs Health Care SystemMinneapolisUSA
  3. 3.Minnesota Gastroenterology, P.A.St. PaulUSA

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