Response to “A Psychological Perspective on Factors Predicting Prophylactic Salpingo-Oophorectomy in a Sample of Italian Women from the General Population. Results from a Hypothetical Study in the Context of BRCA Mutations”
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This letter is in response to the Gavaruzzi et al. (2017) article detailing their study regarding healthy women’s hypothetical preferences about prophylactic bilateral salpingo-oophorectomy (BSO) after receiving information about BRCA1/2 cancer risks and preventative options. Gavaruzzi et al. (2017) provided women with information regarding the ovarian cancer risk for BRCA1/2 mutation carriers as well as their residual risk for ovarian cancer after receiving prophylactic BSO. The article indicated that they reported to their study participants that the residual risk for ovarian cancer in BRCA1-positive women is 12% and for BRCA2-positive women is 4%. Gavaruzzi et al. (2017) then cited the Mavaddat et al. (2013) article as the source for this information.
A review of the literature on residual ovarian/primary peritoneal cancer risks after prophylactic BSO indicates that these numbers are inaccurate. The Mavaddat et al. (2013) article didn’t investigate or report on information...
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Conflict of Interest
Devin M. Cox declares that he has no conflict of interest.
- Finch, A. P. M., Lubinsky, J., Moller, P., Singer, C. F., Karlan, B., Senter, L., et al. (2014). Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. Journal of Clinical Oncology, 32(15), 1547–1553. https://doi.org/10.1200/JCO.2013.53.2820.CrossRefPubMedPubMedCentralGoogle Scholar
- Gavaruzzi, T., Tasso, A., Franiuk, M., Varesco, L., & Lotto, L. (2017). A psychological perspective on factors predicting prophylactic salpingo-oophorectomy in a sample of italian women from the general population. Results from a hypothetical study in the context of BRCA mutations. Journal of Genetic Counseling, 26, 1144–1152. https://doi.org/10.1007/s10897-017-0093-8.CrossRefPubMedPubMedCentralGoogle Scholar