Letter to the Editor: Response to Cox (2018)
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This letter is in response to the comment by Cox (2018), who appeared to be concerned by the figures we presented to participants about the residual risk for ovarian cancer after bilateral risk-reducing salpingo-oophorectomy (RRSO). We agree with the fact that the presence of a residual cancer risk after prophylactic surgery is an important element of discussion during post-test genetic counseling and the subsequent decision-making process. However, at present, we don’t have robust evidence of these figures in real-life high-risk programs. For this reason, we decided to take a conservative approach and, as hypothesized by Cox, we used “…the 80% reduction in risk for ovarian cancer reported in Finch et al. (2014), in conjunction with the lifetime risks reported by Mavaddat et al. (2013)”, instead of using lower figures.
Specifically, we first considered risk figures in Mavaddat et al. (2013), who estimated the average cumulative risks for ovarian cancer by age 70 to be 59% for BRCA1...
- Cox, D. (2018). Letter to the Editor: Response to “A psychological perspective on factors predicting prophylactic salpingo-oophorectomy in a sample of Italian women from the general population. Results from a hypothetical study in the context of BRCA mutations.” Journal of Genetic Counseling. https://doi.org/10.1007/s10897-018-0280-2.CrossRefPubMedGoogle Scholar
- Gavaruzzi, T., Tasso, A., Franiuk, M., Varesco, L., & Lotto, L. (2017). A psychological perspective on factors predicting prophylactic salpingo-oophorectomy in a sample of Italian women from the general population. Results from a hypothetical study in the context of BRCA mutations. Journal of Genetic Counseling, 26, 1144–1152.CrossRefPubMedGoogle Scholar