An Imidazo[1,5-α]Pyridine-Based Fluorometric Chemodosimeter for the Highly Selective Detection of Hypochlorite in Aqueous Media

  • Suh Mi Hwang
  • Dongju Yun
  • Cheal KimEmail author


A new fluorometric chemodosimeter 2-amino-3-(((E)-3-(1-phenylimidazo[1,5-α]pyridin-3-yl)benzylidene)amino)maleonitrile (BPI-MAL) has been designed and synthesized for sensing hypochlorite. BPI-MAL showed a selective turn-on fluorescence for ClO through hypochlorite-promoted de-diaminomaleonitrile reaction. It also could detect ClO in the presence of various competitive anions including reactive oxygen species. Interestingly, sensor BPI-MAL was successfully applied as a fluorescent test kit for ClO determination. The sensing property and mechanism of BPI-MAL toward ClO were studied by fluorescence and UV-vis spectroscopy, NMR titration and DFT calculations.


Hypochlorite Fluorescent chemodosimeter Imidazo[1,5-a]pyridine Test kit Theoretical calculations 



National Research Foundation of Korea and Korea Environment Industry & Technology Institute (NRF-2018R1A2B6001686 and KEITI-2016001970001) kindly supported this work.

Supplementary material

10895_2019_2355_MOESM1_ESM.docx (426 kb)
ESM 1 (DOCX 426 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Fine ChemistrySeoul National University of Science and TechnologySeoulSouth Korea

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