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A Fluorescent Turn-On Carbazole-Rhodanine Based Sensor for Detection of Ag+ Ions and Application in Ag+ Ions Imaging in Cancer Cells

  • Denzil Britto Christopher Leslee
  • Sekar Karuppannan
  • Muthu Vengaian Karmegam
  • Sivaraman Gandhi
  • Singaravadivel Subramanian
ORIGINAL ARTICLE
  • 57 Downloads

Abstract

Carbazole – Rhodanine conjugate is an effective fluorescent host for silver ions through fluorometric transformation from green to red color with a hyperchromic emission. An intramolecular charge transfer process derived from carbazole towards rhodanine favors interaction of thiocarbonyl S and carboxylic acid O of the rhodanine moiety towards Ag+ ion. Carbazole - rhodanine dyad accomplishes the lowest detection limit of 12.8 × 10−9 M and high quantum efficiency. A fluorescence reversibility of the probe with I ion surges reutilization of sensor molecule as an Ag+ ion probe with minimal loss in the fluorescent efficiency. This fluorescent ligand is a biocompatible probe and is also a proficient candidate for fluorescent imaging of Ag+ ion in live cells.

Keywords

Fluorescent sensor Silver ion Carbazole Rhodanine Internal charge transfer Cell imaging 

Notes

Acknowledgements

C. Denzil Britto is thankful to DST-SERB, New Delhi, India, for project fellowship and K. Sekar is grateful to DST-SERB, New Delhi, India, for financial support. (Grant No: SB/FT/CS-062/2013)

Supplementary material

10895_2018_2312_MOESM1_ESM.docx (5.1 mb)
ESM 1 (DOCX 5.13 mb)

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Authors and Affiliations

  1. 1.Department of ChemistryAnna University – University College of EngineeringDindigulIndia
  2. 2.Institute for stem cell biology and regenerative medicineBangaloreIndia
  3. 3.Department of ChemistrySSM Institute of Engineering and TechnologyDindigulIndia

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