Dose-Response Association between Exercise Intensity and Manual Motor Performance in Individuals with Down Syndrome: a Preliminary Study

  • C.-C. (J.J.) ChenEmail author
  • S. D. R. Ringenbach


This study was aimed at investigating the dose-response relationship between acute exercise and its effects on manual motor control mediated by the intensity of exercise in individuals with Down syndrome (DS). Participants were randomized into vigorous-intensity exercise (i.e., 75–85% of predicted MaxHR), moderate-intensity exercise (i.e., 50–75% of predicted MaxHR) or control groups. The exercise groups performed an incremental walking protocol on the treadmill and the control group watched a video for 20-min. Measures of grip strength and manual dexterity were tested pre- and post- intervention. A quadric trend was seen in grip strength, such that the moderate-intensity exercise was beneficial for grip force production. However, inconsistent with previous studies, neither a quadric trend nor a linear trend was evident in the performance of the Purdue Pegboard Test. Thus, a large sample size and brain imaging measures are needed to explore the underlying mechanisms involved in individuals with DS.


Intellectual disabilities Muscular strength Exercise Does-response relationship 


Compliance with Ethical Standards


This research was supported by The Graduate Research Support Program at Arizona State University and Health Professionals Student Grant Program from Special Olympics.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors have no conflicts of interest to declare in reference to this work.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of KinesiologyMississippi State UniversityMississippi StateUSA
  2. 2.College of Health SolutionsArizona State UniversityPhoenixUSA

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