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Systematic Review: Pain and Emotional Functioning in Pediatric Sickle Cell Disease

  • Steven K. ReaderEmail author
  • Laura M. Rockman
  • Katherine M. Okonak
  • Nicole M. Ruppe
  • Colleen N. Keeler
  • Anne E. Kazak
Article
  • 18 Downloads

Abstract

The objective of this systematic review was to assess the relationship between pain (frequency/intensity/duration, impairment, coping) and emotional functioning in pediatric Sickle Cell Disease, and evaluate the state of the literature. Studies were included if they met each of the following criteria: (a) primarily pediatric sample of youth or young adults up to age 21 years with SCD, (b) examined emotional functioning including anxiety and/or depressive and/or internalizing symptoms, and/or affect, (c) examined pain intensity/frequency/duration and/or pain-related impairment and/or pain coping as it relates to emotional functioning, as defined above. Using the established guidelines for systematic reviews, we searched PsycINFO, PubMED, and CINAHL databases for studies published through June 2018. Screening resulted in 33 studies meeting inclusion criteria. Study data were extracted and evaluated for scientific merit, resulting in four studies being removed. 29 studies were included in the final synthesis. Studies provide strongest evidence of a relationship between increased pain frequency and higher depressive and anxiety symptoms. There are moderate-to-strong associations between pain-related impairment and depressive symptoms, and small-to-strong associations between pain-related impairment and anxiety. When examining pain-coping strategies, maladaptive cognitive strategies show the strongest association with emotional functioning. There is a need for more adequately powered, prospective studies based on theoretical frameworks in order to advance our understanding of the relationship between pain and emotional functioning in pediatric SCD.

Keywords

Systematic review Sickle cell disease Pain Depression Anxiety 

Notes

Acknowledgements

This work was supported by a grant from the National Institute of General Medical Sciences of the National Institutes of Health (Grant No. P20GM109021) and the Nemours Center for Healthcare Delivery Science of the Nemours Children’s Health System. The authors thank Dr. Melissa Alderfer for her consultation on this systematic review.

Compliance with Ethical Standards

Conflict of interest

Steven K. Reader, Laura M. Rockman, Katherine M. Okonak, Nicole M. Ruppe, Colleen N. Keeler, and Anne E. Kazak declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. Alderfer, M. A., Long, K. A., Lown, E. A., Marsland, A. L., Ostrowski, N. L., Hock, J. M., & Ewing, L. J. (2010). Psychosocial adjustment of siblings of children with cancer: A systematic review. Psycho-oncology, 19, 789–805.  https://doi.org/10.1002/pon.1638.CrossRefGoogle Scholar
  2. Bakshi, N., Lukombo, I., Belfer, I., & Krishnamurti, L. (2018). Pain catastrophizing is associated with poorer health-related quality of life in pediatric patients with sickle cell disease. Journal of Pain Research, 11, 947–953.CrossRefGoogle Scholar
  3. Bakshi, N., Lukombo, I., Shnol, H., Belfer, I., & Krishnamurti, L. (2017). Psychological characteristics and pain frequency are associated with experimental pain sensitivity in pediatric patients with sickle cell disease. The Journal of Pain, 18, 1216–1228.CrossRefGoogle Scholar
  4. Barakat, L. P., Patterson, C. A., Daniel, L. C., & Dampier, C. (2008). Quality of life among adolescents with sickle cell disease: Mediation of pain by internalizing symptoms and parenting stress. Health and Quality of Life Outcomes, 6, 1–9.CrossRefGoogle Scholar
  5. Barakat, L. P., Schwartz, L. A., Simon, K., & Radcliffe, J. (2007). Negative thinking as a coping strategy mediator of pain and internalizing symptoms in adolescents with sickle cell disease. Journal of Behavioral Medicine, 30, 199–208.  https://doi.org/10.1007/s10865-007-9103-x.CrossRefGoogle Scholar
  6. Bennett, D. S. (1994). Depression among children with chronic medical problems: A meta-analysis. Journal of Pediatric Psychology, 19, 149–169.CrossRefGoogle Scholar
  7. Benton, T. D., Ifeagwu, J. A., & Smith-Whitley, K. (2007). Anxiety and depression in children and adolescents with sickle cell disease. Current Psychiatry Reports, 9, 114–121.CrossRefGoogle Scholar
  8. Burlew, K., Telfair, J., Colangelo, L., & Wright, E. C. (2000). Factors that influence adolescent adaptation to sickle cell disease. Journal of Pediatric Psychology, 25, 287–299.CrossRefGoogle Scholar
  9. Cartwright-Hatton, S., McNicol, K., & Doubleday, E. (2006). Anxiety in a neglected population: Prevalence of anxiety disorders in pre-adolescent children. Clinical Psychology Review, 26, 817–833.CrossRefGoogle Scholar
  10. Casey, R., Brown, R. T., & Bakeman, R. (2000). Predicting adjustment in children and adolescents with Sickle Cell Disease: A test of the Risk-Resistance-Adaptation model. Rehabilitation Psychology, 45, 155–178.CrossRefGoogle Scholar
  11. Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates.Google Scholar
  12. Cozzi, L., & Tryon, W. W. (1987). The effectiveness of biofeedback-assisted relaxation in modifying sickle cell disease. Biofeedback and Self-Regulation, 12, 51–61.  https://doi.org/10.1007/BF01000078.CrossRefGoogle Scholar
  13. Dampier, C., Barry, V., Gross, H. E., Lui, Y., Thornburg, C. D., DeWalt, D. A., & Reeve, B. B. (2016). Initial evaluation of the pediatric PROMIS® health domains in children and adolescents with sickle cell disease. Pediatric Blood Cancer, 63, 1031–1037.  https://doi.org/10.1002/pbc.25944.CrossRefGoogle Scholar
  14. Eiser, C. (1990). Psychological effects of chronic disease. Journal of Child Psychology and Psychiatry, 31, 85–98.CrossRefGoogle Scholar
  15. Fisher, K., Laikin, A. M., Howard Sharp, K. M., Criddle, C. A., Palermo, T. M., & Karlson, C. W. (2018). Temporal relationship between daily pain and actigraphy sleep patterns in pediatric sickle cell disease. Journal of Behavioral Medicine, 41, 416–422.  https://doi.org/10.1007/s10865-018-9918-7.CrossRefGoogle Scholar
  16. Gil, K. M., Anthony, K. K., Carson, J. W., Redding-Lallinger, R., Daeschner, C. W., & Ware, R. E. (2001). Daily coping practice predicts treatment effects in children with sickle cell disease. Journal of Pediatric Psychology, 26, 163–173.  https://doi.org/10.1093/jpepsy/26.3.163.CrossRefGoogle Scholar
  17. Gil, K. M., Carson, J. W., Porter, L. S., Ready, J., Valrie, C., Redding-Lallinger, R., & Daeschner, C. (2003). Daily stress and mood and their association with pain, health-care use, and school activity in adolescents with sickle cell disease. Journal of Pediatric Psychology, 28, 363–373.  https://doi.org/10.1093/jpepsy/jsg026.CrossRefGoogle Scholar
  18. Gil, K. M., Edens, J. L., Wilson, J. J., Raezer, L. B., Kinney, T. R., Schultz, W. H., & Daeschner, C. (1997). Coping strategies and laboratory pain in children with sickle cell disease. Annals of Behavioral Medicine, 19, 22–29.CrossRefGoogle Scholar
  19. Gil, K. M., Williams, D. A., Thompson, R. J., & Kinney, T. R. (1991). Sickle cell disease in children and adolescents: The relation of child and parent pain coping strategies to adjustment. Journal of Pediatric Psychology, 16, 643–663.CrossRefGoogle Scholar
  20. Goldstein-Leever, A., Cohen, L. L., Dampier, C., & Sil, S. (2018). Parent pain catastrophizing predicts child depressive symptoms in youth with sickle cell disease. Pediatric Blood & Cancer, 65, e27027.  https://doi.org/10.1002/pbc.27027.CrossRefGoogle Scholar
  21. Graumlich, S. E., Powers, S. W., Byars, K. C., Schwarber, L. A., Mitchell, M. J., & Kalinyak, K. A. (2001). Multidimensional assessment of pain in pediatric sickle cell disease. Journal of Pediatric Psychology, 26, 203–214.CrossRefGoogle Scholar
  22. Graves, J. K., Hodge, C., & Jacob, E. (2016). Depression, anxiety, and quality of life in children and adolescents with sickle cell disease. Pediatric Nursing, 42, 113.Google Scholar
  23. Hassell, K. L. (2010). Population estimates of sickle cell disease in the U.S. American Journal of Preventative Medicine, 38, S512–S521.CrossRefGoogle Scholar
  24. Hoff, A. L., Palermo, T. M., Schluchter, M., Zebracki, K., & Drotar, D. (2006). Longitudinal relationships of depressive symptoms to pain intensity and functional disability among children with disease-related pain. Journal of Pediatric Psychology, 31, 1046–1056.  https://doi.org/10.1093/jpepsy/jsj076.CrossRefGoogle Scholar
  25. Jerrell, J. M., Tripathi, A., & McIntyre, R. S. (2011). Prevalence and treatment of depression in children and adolescents with sickle cell disease: A retrospective cohort study. The Primary Care Companion for CNS Disorders.  https://doi.org/10.4088/pcc.10m01063.Google Scholar
  26. Karlson, C. W., Baker, A. M., Bromberg, M. H., Elkin, T. D., Majumdar, S., & Palermo, T. M. (2017). Daily pain, physical activity, and home fluid intake in pediatric sickle cell disease. Journal of Pediatric Psychology, 42, 335–344.  https://doi.org/10.1093/jpepsy/jsw061.Google Scholar
  27. Lemanek, K. L., Hahn, A., & McNaull, M. (2017). Sickle cell disease. In M. C. Roberts & R. G. Steele (Eds.), Handbook of pediatric psychology (pp. 269–283). New York: Guilford Press.Google Scholar
  28. Lemanek, K. L., Ranalli, M., & Lukens, C. (2009). A randomized controlled trial of massage therapy in children with sickle cell disease. Journal of Pediatric Psychology, 34, 1091–1096.  https://doi.org/10.1093/jpepsy/jsp015.CrossRefGoogle Scholar
  29. Merikangas, K.R., He, J., Burstein, M., Swanson, S.A., Avenevoli, S., Cui, L., … Swendsen, J. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: Results from the National Comorbidity Survey Replication—Adolescent Supplement. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 980–989.Google Scholar
  30. Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med, 6, e1000097.  https://doi.org/10.1371/journal.pmed1000097.CrossRefGoogle Scholar
  31. Mojtabai, R., Olfson, M., & Han, B. (2016). National trends in the prevalence and treatment of depression in adolescents and young adults. Pediatrics, 138, e20161878.  https://doi.org/10.1542/peds.2016-1878.CrossRefGoogle Scholar
  32. Moody, K., Abrahams, B., Baker, R., Santizo, R., Manwani, D., Carullo, V., … Carroll, A. (2017). A randomized trial of yoga for children hospitalized with sickle cell vaso-occlusive crisis. Journal of Pain and Symptom Management, 53, 1026–1034.  https://doi.org/10.1016/j.jpainsymman.2016.12.351.
  33. Morgan, G. A., Gliner, J. A., & Harmon, R. J. (1999). Quantitative research approaches. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1595–1597.CrossRefGoogle Scholar
  34. Neale, J., & Liebert, R. (1986). Science and behavior: An introduction to methods of research. Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
  35. Noll, R. B., Vannatta, K., Koontz, K., Kalinyak, K., Bukowski, W. M., & Davis, W. H. (1996). Peer relationships and emotional well-being of youngsters with sickle cell disease. Child Development, 67, 423–436.Google Scholar
  36. Palermo, T. M. (2013). New guidelines for publishing review articles in JPP: Systematic reviews and topical reviews. Journal of Pediatric Psychology, 38, 5–9.CrossRefGoogle Scholar
  37. Palermo, T. M., Platt-Houston, C., Kiska, R. E., & Berman, B. (2005). Headache symptoms in pediatric sickle cell patients. Journal of Pediatric Hemotology/Oncology, 27, 420–424.  https://doi.org/10.1097/01.mph.0000175408.27180.8e.CrossRefGoogle Scholar
  38. Palermo, T. M., Riley, C. A., & Mitchell, B. A. (2008). Daily functioning and quality of life in children with sickle cell disease pain: Relationship with family and neighborhood socioeconomic distress. The Journal of Pain, 9, 833–840.  https://doi.org/10.1016/j.jpain.2008.04.002.CrossRefGoogle Scholar
  39. Palermo, T. M., Valrie, C. R., & Karlson, C. W. (2014). Family and parent influences on pediatric chronic pain: A developmental perspective. American Psychologist, 69, 142–152.CrossRefGoogle Scholar
  40. Panepinto, J. A., & Bonner, M. (2012). Health-related quality of life in Sickle Cell Disease: Past, present, and future. Pediatric Blood & Cancer, 59, 377–385.CrossRefGoogle Scholar
  41. Peterson, C. C., Palermo, T. M., Swift, E., Beebe, A., & Drotar, D. (2005). Assessment of psychoeducational needs in a clinical sample of children with sickle cell disease. Children’s Health Care, 34, 133–148.CrossRefGoogle Scholar
  42. Pillai Riddell, R., Racine, N., Craig, K. D., & Campbell, L. (2013). Psychological theories and biopsychosocial models in paediatric pain. In P. J. McGrath, et al. (Eds.), Oxford textbook of paediatric pain (pp. 85–94). Oxford: Oxford University Press.CrossRefGoogle Scholar
  43. Pinquart, M., & Shen, Y. (2010). Depressive symptoms in children and adolescents with chronic physical illness: An updated meta-analysis. Journal of Pediatric Psychology, 36, 375–384.  https://doi.org/10.1093/jpepsy/jsq104.CrossRefGoogle Scholar
  44. Schlenz, A. M., Schatz, J., & Roberts, C. W. (2016). Examining biopsychosocial factors in relation to multiple pain features in pediatric sickle cell disease. Journal of Pediatric Psychology, 41, 930–940.  https://doi.org/10.1093/jpepsy/jsw003.CrossRefGoogle Scholar
  45. Sil, S., Cohen, L. L., & Dampier, C. (2016). Psychosocial and functional outcomes in youth with chronic sickle cell pain. Clinical Journal of Pain, 32, 527–533.  https://doi.org/10.1097/AJP.0000000000000289.CrossRefGoogle Scholar
  46. Thompson, R. J., Gil, K. M., Burbach, D. J., Keith, B. R., & Kinney, T. R. (1993). Role of child and maternal processes in the psychological adjustment of children with sickle cell disease. Journal of Consulting and Clinical Psychology, 61, 468–474.CrossRefGoogle Scholar
  47. Thompson, R. J., Gil, K. M., Keith, B. R., Gustafson, K. E., George, L. K., & Kinney, T. R. (1994). Psychological adjustment of children with sickle cell disease: Stability and change over a 10-month period. Journal of Consulting and Clinical Psychology, 62, 856–860.CrossRefGoogle Scholar
  48. Tsao, J. C., Jacob, E., Seidman, L. C., Lewis, M. A., & Zeltzer, L. K. (2014). Psychological aspects and hospitalization for pain crises in youth with sickle-cell disease. Journal of Health Psychology, 19, 407–416.  https://doi.org/10.1177/1359105312471570.CrossRefGoogle Scholar
  49. Unal, S., Toros, F., Kutuk, M. O., & Uyaniker, M. G. (2011). Evaluation of the psychological problems of children with sickle cell anemia and their families. Pediatric Hematology and Oncology, 28, 321–328.CrossRefGoogle Scholar
  50. Valrie, C. R., Gil, K. M., Redding-Iallinger, R., & Daeschner, C. (2008). Brief report: Daily mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease. Journal of Pediatric Psychology, 33, 317–322.  https://doi.org/10.1093/jpepsy/jsm058.CrossRefGoogle Scholar
  51. Wagner, J. L., Connelly, M., Brown, R. T., Taylor, L. C., Rittle, C., & Wall-Cloues, B. (2004). Predictors of social anxiety in children and adolescents with sickle cell disease. Journal of Clinical Psychology in Medical Setting, 11, 243–252.CrossRefGoogle Scholar
  52. Wakefield, E. O., Popp, J. M., Dale, L. P., Santanelli, J. P., Pantaleao, A., & Zempsky, W. T. (2017). Perceived racial bias and health-related stigma among youth with sickle cell disease. Journal of Developmental and Behavioral Pediatrics, 38, 129–134.  https://doi.org/10.1097/DBP.0000000000000381.Google Scholar
  53. Walco, G. A., & Dampier, C. D. (1990). Pain in children and adolescents with sickle cell disease: A descriptive study. Journal of Pediatric Psychology, 15, 643–658.CrossRefGoogle Scholar
  54. Wallander, J. L., & Varni, J. W. (1992). Adjustment in children with chronic physical disorders: Programmatic research on a disability-stress-coping model. In A. M. La Greca, L. J. Siegel, J. L. Wallander, & C. E. Walker (Eds.), Advances in pediatric psychology. Stress and coping in child health (pp. 279–298). New York: Guilford Press.Google Scholar
  55. Wallander, J., & Varni, J. W. (1998). Effects of pediatric chronic physical disorders on child and family adjustment. Journal of Child Psychology and Psychiatry, 39, 29–46.CrossRefGoogle Scholar
  56. Zempsky, W. T., Palermo, T. M., Corsi, J. M., Lewandowski, A. S., Zhou, C., & Casella, J. F. (2013). Daily changes in pain, mood and physical function in youth hospitalized for sickle cell disease pain. Pain Research & Management, 18, 33–38.CrossRefGoogle Scholar
  57. Zempsky, W. T., Wakefield, E. O., Santanelli, J. P., New, T., Smith-Whitley, K., Casella, J. F., & Palermo, T. M. (2017). Widespread pain among youth with sickle cell disease hospitalized with vaso-occlusive pain. Clinical Journal of Pain, 33, 335–339.  https://doi.org/10.1097/AJP.0000000000000403.CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center for Healthcare Delivery ScienceThe Nemours Children’s Health SystemWilmingtonUSA
  2. 2.Sidney Kimmel Medical College of Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Auckland District Health BoardAucklandNew Zealand

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