Blood CO2 exchange monitoring, Haldane effect and other calculations in sepsis and critical illness
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We would like to congratulate the Authors  for their interesting study and their effort to progressively determine the dominant factor (pH), among the many factors affecting PcvaCO2 and PcvaCO2/CavO2. Indeed, this is important also for clinical practice, because a busy ICU physician may be reluctant to deal with too many symbols, variables and equations, while simpler and well defined final messages are better accepted.
The group of the Authors previously emphasized in another article published in this same journal the importance of the Haldane effect in peculiar conditions (venous hyperoxia) . There, they underscored the importance of the Haldane effect, and in our opinion their conclusions could be reinforced by the significant decrease in central venous pH in hyperoxia, an aspect that was not mentioned in the article. Indeed, another side of the Haldane effect is the O2-linked H+ exchange (which is related, although not quantitatively equivalent, to the O2-linked CO2...
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Conflict of interest
The authors declare no conflicts of interest.
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