Unveiling Antimicrobial Activity of Metal Iodide (CuI, AgI, and PbI2) Nanoparticles: Towards Biomedical Surfaces Applications

  • A. S. Awed
  • Gharieb S. El-SayyadEmail author
  • Ahmed El-ghandour
  • Mohamed Farhat O. Hameed
  • M. I. A. Abdel Maksoud
  • Ahmed I. El-Batal
  • S. S. A. ObayyaEmail author
Original Paper


Synthesizing nanoparticles (NPs) capable of hindrance the microbial colonization is a global demand. Such NPs can prevent emerging infectious diseases that harm the public health. In this paper, a co-precipitation method is employed to synthesize colloidal of metal iodide, namely copper iodide (CuI), silver iodide (AgI), and lead iodide (PbI2). Subsequently, EDS, XRD, HRSEM with mapping technique are conducted to study the structural properties of the as-synthesized samples. Additionally, their absorption is highlighted using UV/Vis spectroscopy. NPs with average crystallite size equals to 54.98, 57.02, and 23.47 nm for PbI2, CuI, and AgI, respectively are calculated. SEM images show that PbI2 consists of randomly-oriented dense nanoflakes of iodide. CuI NPs have a dense medium with tiny particles adhered to larger particles related to copper. Further, AgI sample contains agglomerated crystallites with a combination of small and large sizes. Antimicrobial activity of the samples against all tested standard pathogens is examined. In particular, AgI NPs have a prominent antimicrobial capability against Escherichia coli, Candida albicans and Staphylococcus aureus (ZOI of 18.0, 16.0 and 15.0 mm, respectively). Therefore, the AgI NPs can be safely used in solving serious industrial, pharmaceutical and medical challenges and particularly in the treatment of surface infectious diseases.


Silver iodide Copper iodide Lead iodide Antimicrobial activity Bio-medical surfaces applications 



The authors would like to thank the Nanotechnology Research Unit (P.I. Prof. Dr. Ahmed I. El-Batal), Drug Microbiology Lab., Drug Radiation Research Department, NCRRT, Egypt, for financing and supporting this study under the project “Nutraceuticals and Functional Foods Production by using Nano/Biotechnological and Irradiation Processes”. Also, the authors would like to thank Prof. Mohamed Gobara (Chemical Engineering Department, Military Technical College, Egyptian Armed Forces), and Zeiss microscope team in Cairo for their invaluable advice during this study.


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Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research Involving Human Participation and/or Animals

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Informed consent

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Ethical approval

Not applicable.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Center of Photonics and Smart MaterialsZewail City of Science and TechnologyGizaEgypt
  2. 2.Higher Institute of Engineering and TechnologyManzalaEgypt
  3. 3.Drug Radiation Research DepartmentNational Center for Radiation Research and Technology (NCRRT), Atomic Energy AuthorityCairoEgypt
  4. 4.Chemical Engineering Department, Military Technical CollegeEgyptian Armed ForcesCairoEgypt
  5. 5.Nanoelectronics and Nanotechnology and Engineering ProgramZewail City of Science and TechnologyGizaEgypt
  6. 6.Faculty of EngineeringMansoura UniversityMansouraEgypt
  7. 7.Materials Science Lab, Radiation Physics DepartmentNational Center for Radiation Research and Technology (NCRRT), Atomic Energy AuthorityCairoEgypt

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