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A New Cluster-Based MOF for Selective Gas Sorption and Treatment Effect on Acute glomerulonephritis by Reducing NF-κb Pathway Activation and Cytokines Release

  • Gang Ma
  • Jian-Jun Zhang
  • Li Sun
  • Yu-Xiang Xu
  • Hong-Li Gao
  • Heng-Yuan Zhang
  • Xiao-Wen HeEmail author
Original Paper
  • 24 Downloads

Abstract

A novel Co(II)-containing metal–organic framework [Co3(OH)2(H2TCPP)2](DMF)3 (1) based on a linear trinuclear Co(II) cluster-based unit has been successfully prepared by using a nanosized tetracarboxylate ligand 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) as the organic building block under the solvothermal reaction. Gas adsorption studies reveal that the mixtures of C2H2/CH4 and C2H2/CO2 could be selectively separated by the obtained resulting solvent free 1 (denoted as 1a hereafter). To deep evaluate the protective function of complex for acute glomerulonephritis (AGN) disease in vitro, the following experiments were conducted. (a) Real time Reverse transcription-Polymerase Chain Reaction (RT-PCR) was carried out to determine the relative expression of Nuclear factor kappa beta (nf-κb) and Tumor Necrosis Factor-α (tnf-α) in the glomerulus cells after bacterial infection along with complex 1 treatment. (b) The enzyme linked immunosorbent assay (ELISA) was conducted to determine the IL-1β and IL-6 released by glomerular cells after complex 1 treatment. (c) The results obtained through molecular docking exhibited possible regulation mechanism on the binding affinity between compound 1 and target protein.

Keywords

MOF Co(II)-complex Porous framework C2H2/CO2 separation Glomerular cells Inflammatory response Molecular docking 

Notes

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Gang Ma
    • 1
  • Jian-Jun Zhang
    • 2
  • Li Sun
    • 1
  • Yu-Xiang Xu
    • 3
  • Hong-Li Gao
    • 4
  • Heng-Yuan Zhang
    • 5
  • Xiao-Wen He
    • 3
    Email author
  1. 1.Infectious DiseaseThe Affiliated Hospital of Northwest University, Xi’an No.3 HospitalXi’anChina
  2. 2.Infectious DiseaseYan’an People’s HospitalYan’anChina
  3. 3.Kidney Internal MedicineXi’an XD Group HospitalXi’anChina
  4. 4.Medical SchoolHubei Minzu UniversityEnshiChina
  5. 5.Department of NephropathyXiamen UniversityXiamenChina

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