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Synthesis, Characterization and Evaluation of Liponiosome Containing Ginger Extract as a New Strategy for Potent Antifungal Formulation

  • Mahya Mohammadi
  • Bibi Fatemeh Haghirosadat
  • Mohaddeseh larypoor
  • Raheleh Ehsani
  • Fatemeh YazdianEmail author
  • Hamid RashediEmail author
  • Shabnam Jahanizadeh
  • Anosheh Rahmani
Original Paper
  • 31 Downloads

Abstract

Aflatoxins are natural fungous toxins made by Aspergillus species. The toxins can cause tissue necrosis. In this study, nanoliponiosomes containing ginger extract were synthetized and their antifungal effect on the growth and Aflatoxin production of Aspergillus flavus and Aspergillus parasiticus fungi was studied. Physiochemical characteristics of the sample were determined using XRD, FTIR, AFM, DLS and SEM. The resultant nanostructure can operation as an angiogenesis promoter and provide antifungal nanocarrier for improving the wound healing process. Antifungal activity of ginger extract was determined by disc diffusion and microplate dilution methods. The inhibitory effect of extract on Aflatoxin-B1 production was investigated using MIC method. Ginger concentration, cholesterol%, SPAN-60 and DPPC% were optimized by response surface method. FTIR analysis showed that ginger extract and nanoliponiosome had no chemical interaction resulting in the change of functional groups. SEM observation showed the spherical morphology of particles and the average size of 95 nm. It was also found out that ginger extract had a stronger antifungal effect against Aspergillus flavus fungus compared to Aspergillus parasiticus fungus. The results of this study showed that the ginger extract loaded nanoliponiosomes can be promising antifungal agents for improving wound healing process with high antifungal effects and low side effects.

Keywords

Nanoliponiosome Ginger extract Aspergillus flavus Wound healing Aflatoxin-B1 

Notes

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Mahya Mohammadi
    • 1
  • Bibi Fatemeh Haghirosadat
    • 2
    • 3
  • Mohaddeseh larypoor
    • 4
  • Raheleh Ehsani
    • 2
  • Fatemeh Yazdian
    • 5
    Email author
  • Hamid Rashedi
    • 6
    Email author
  • Shabnam Jahanizadeh
    • 7
  • Anosheh Rahmani
    • 8
  1. 1.Department of Biotechnology, Tehran North BranchIslamic Azad UniversityTehranIran
  2. 2.Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences InstituteShahid Sadoughi University of Medical SciencesYazdIran
  3. 3.Department of Advanced Medical Sciences and Technologies, School of ParamedicineShahid Sadoughi University of Medical SciencesYazdIran
  4. 4.Department of Biotechnology, Tehran North BranchIslamic Azad UniversityTehranIran
  5. 5.Department of Life Science Engineering, Faculty of New Science and TechnologiesUniversity of TehranTehranIran
  6. 6.Department of Biotechnology, School of Chemical Engineering, College of EngineeringUniversity of TehranTehranIran
  7. 7.Young Researchers and Elite Club, Arak BranchIslamic Azad UniversityArakIran
  8. 8.Scientific Member and Assistant Professor of Food and Agriculture FacultyStandard Research Institute (SRI)KarajIran

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