Emerging Theranostic Silver Nanomaterials to Combat Colorectal Cancer: A Systematic Review

  • Hamed BarabadiEmail author
  • Hossein Vahidi
  • Kaveh Damavandi Kamali
  • Masoumeh RashediEmail author
  • Omid Hosseini
  • Ahmad Reza Golnaraghi Ghomi
  • Muthupandian SaravananEmail author
Review Paper


Cancer nanotechnology has emerged as the promising cutting edge of researches to combat cancer. Cancer nanotechnology can be described as the science of synthesizing and utilizing nanoscale materials for cancer theranostics. Colorectal cancer is a common type of cancers worldwide and a leading cause of cancer-related death. Up to know, a number of laboratory studies represented the anticancer potential of biogenic silver nanoparticles (AgNPs) against colorectal cancers. This study was aimed to systematically review the published articles to assess the cytotoxicity of biogenic AgNPs against colorectal cancer cells through the laboratory in vitro investigations. The international electronic databases involving Cochrane, PubMed, Scopus, Web of Science, ProQuest, Science Direct, and Embase were searched to identify the records. The results revealed different biological resources for the synthesis of AgNPs such as plants, bacteria, fungi, and algae. Most of the AgNPs were synthesized with spherical morphology and particle size of less than 100 nm. Most of the studies showed considerable anticancer effects of AgNPs with the half maximal inhibitory concentration (IC50) against colorectal cancer cells. The findings of this study promise the bright future of biogenic AgNPs for colorectal cancer therapy.

Graphic Abstract


Colorectal cancer Silver nanoparticles Nanotoxicity Biosynthesis Systematic review 



This work was financially supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran [Grant Number: 19352].

Compliance with Ethical Standards

Conflict of interests

The authors declare no conflict of interests.


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Authors and Affiliations

  1. 1.Department of Pharmaceutical Biotechnology, School of PharmacyShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Golestan University of Medical Sciences, Food and Drug AdministrationGorganIran
  3. 3.Student Research Committee, School of MedicineGonabad University of Medical SciencesGonabadIran
  4. 4.Shahid Beheshti University of Medical SciencesTehranIran
  5. 5.Fouman Faculty of Engineering, College of EngineeringUniversity of TehranFoumanIran
  6. 6.Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health SciencesMekelle UniversityMekelleEthiopia

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